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Peptide record

TPDB43326

L-FP21-PEG-PEI/pGRO-α Anticancer standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB43326
L-FP21-PEG-PEI/pGRO-α
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 21-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
Chemical: conjugated to polyethylenimine (PEI) and methoxy polyethylene glycol (mPEG)
Sequence
YTRDLVYGDPARPGIQGTGTF
Physicochemical Analysis
C102H154N28O32
NCEHKMSW
G
2284.51
6.80
2
2
7
-0
2.04
-0.567
55.71
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
130.44
6
Residue Composition
number
1
A
2
R
0
N
2
D
0
C
0
E
1
Q
4
G
0
H
1
I
1
L
0
K
0
M
1
F
2
P
0
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 2 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 2 S: 0 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
21
C102H154N28O32
2284.51
6.80
-0
2.04
-0.567
Free
conjugated to polyethylenimine (PEI) and methoxy polyethylene glycol (mPEG)
L
Linear
Free
Anti-caner, anti-proliferative, anti-tumor
Synthetic
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
IC50 = 23.4 µg/mL
Anticancer
23.4 µg/mL

Target

Ovarian Cancer
HO-8910
Ovary

Assay & Model

CCK-8 assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.