TPDB

3D PDB MODEL

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TPDB ID TPDB43324

Peptide_Name

E3

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

YSINDWH

FASTA

>TPDB43324|Anticancer;Tumor-homing Peptides|length=7
YSINDWH

Formula C43H55N11O13

Absent Amino Acids ARCEQGLKMFPTV

Common Amino Acids NDHISWY

Mass 933.98

PI 4.94

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index -0.36

Hydrophobicity -1.243

Aliphatic Index 55.71

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 748.41

Polar Residues 3

number

0

A

0

R

1

N

1

D

0

C

0

E

0

Q

0

G

1

H

1

I

0

L

0

K

0

M

0

F

0

P

1

S

0

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0

Length

7

Formula

C43H55N11O13

Mass

933.98

PI

4.94

Net Charge

-1

Boman Index

-0.36

Hydrophobicity

-1.243

Motif

YSXNXW and PXNXXN

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel

Homing or Targeting Homing

Target Tumor Esophagus and gastroesophageal cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Screening of specific binding peptide targeting blood vessel of human esophageal cancer in vivo in mice

Year 2011

Reference

Zhi M et al. Chin Med J (Engl). 2011 Feb 124(4):581-5.

Patent US2010/0233161A1

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVivo Model

2-month-old Balb/c mice with human esophageal tumor xenograft, fresh human esophageal cancer tissue in immunosuppressed Balb/c mice

Source Type Phage display library

Phage Display Library M13 phage/C7C peptide library

Comments

The staining distribution of phage with the sequence of PNPNNST was similar to that of the blood vessel marker factor VIII-related antigen staining

InVivo_Model

2-month-old Balb/c mice with human esophageal tumor xenograft, fresh human esophageal cancer tissue in immunosuppressed Balb/c mice

Phage_Display_Library

M13 phage/C7C peptide library