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Peptide record

TPDB43319

Anticancer modified_plain modified

5 amino acids

TPDB ID TPDB43319

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

CancerPPD 2.0 Peptipedia SATPdb dbACP

Sequence_Type

modified_plain

Has_Modification Yes

Description A 5-aa modified anticancer peptide sequence curated from CancerPPD 2.0, Peptipedia, SATPdb, and other sources, without an available 3D structural model.

Modification

Chemical: A* = Cα -dialkylated glycine (Aaa2,2 )

Sequence

YSA*G

FASTA

>TPDB43319|Anticancer|length=5
YSA*G

Formula C17H24N4O7

Absent Amino Acids RNDCEQHILKMFPTWV

Common Amino Acids AGSY

Mass 396.40

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -0.97

Hydrophobicity -0.140

Aliphatic Index 20.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 375.88

Polar Residues 2

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

Formula

C17H24N4O7

Mass

396.40

5.94

Net Charge

-0

Boman Index

-0.97

Hydrophobicity

-0.140

C_terminal_Modification

Free

Chemical_Modification

A* = Cα -dialkylated glycine (Aaa2,2 )

Chirality

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antitumor

Origin

Synthetic Peptide

Evidence 1 Activity

Activity

Activity Raw

2.7% inhibition at 10-6M

Detail Source Activity Anticancer

Target

Cancer Type Larynx Cancer

Cell Line HEp-2

Tissue Affected Larynx

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Raw

2.0% inhibition at 10-5M

Detail Source Activity Anticancer

Target

Cancer Type Larynx Cancer

Cell Line HEp-2

Tissue Affected Larynx

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 3 Activity

Activity

Activity Raw

18.8% inhibition at 10-4M

Detail Source Activity Anticancer

Target

Cancer Type Larynx Cancer

Cell Line HEp-2

Tissue Affected Larynx

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 4 Activity

Activity

Activity Raw

26.7% inhibition at 10-3M

Detail Source Activity Anticancer

Target

Cancer Type Larynx Cancer

Cell Line HEp-2

Tissue Affected Larynx

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 5 Activity

Activity

Activity Raw

9.8% inhibition at 10-6M

Detail Source Activity Anticancer

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 6 Activity

Activity

Activity Raw

7.3% inhibition at 10-5M

Detail Source Activity Anticancer

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 7 Activity

Activity

Activity Raw

9.9% inhibition at 10-4M

Detail Source Activity Anticancer

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 8 Activity

Activity

Activity Raw

28.2% inhibition at 10-3M

Detail Source Activity Anticancer

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 9 Activity

Activity

Activity Raw

1.6% inhibition at 10-6M

Detail Source Activity Anticancer

Target

Cancer Type Skin Cancer

Cell Line HBL

Tissue Affected Skin

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 10 Activity

Activity

Activity Raw

2.9% inhibition at 10-5M

Detail Source Activity Anticancer

Target

Cancer Type Skin Cancer

Cell Line HBL

Tissue Affected Skin

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 11 Activity

Activity

Activity Raw

5.9% inhibition at 10-4M

Detail Source Activity Anticancer

Target

Cancer Type Skin Cancer

Cell Line HBL

Tissue Affected Skin

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 12 Activity

Activity

Activity Raw

17.9% inhibition at 10-3M

Detail Source Activity Anticancer

Target

Cancer Type Skin Cancer

Cell Line HBL

Tissue Affected Skin

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 13 Activity

Activity

Activity Raw

5.4% inhibition at 10-6M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line HT-29

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 14 Activity

Activity

Activity Raw

7.4% inhibition at 10-5M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line HT-29

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 15 Activity

Activity

Activity Raw

9.5% inhibition at 10-4M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line HT-29

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 16 Activity

Activity

Activity Raw

15.7% inhibition at 10-3M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line HT-29

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 17 Activity

Activity

Activity Raw

13.6% inhibition at 10-6M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line SW-620

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 18 Activity

Activity

Activity Raw

20.4% inhibition at 10-5M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line SW-620

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 19 Activity

Activity

Activity Raw

14.4% inhibition at 10-4M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line SW-620

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 20 Activity

Activity

Activity Raw

23.4% inhibition at 10-3M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line SW-620

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 21 Activity

Activity

Activity Raw

2.2% inhibition at 10-6M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line CaCo-2

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 22 Activity

Activity

Activity Raw

4.2% inhibition at 10-5M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line CaCo-2

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 23 Activity

Activity

Activity Raw

6.4% inhibition at 10-4M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line CaCo-2

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 24 Activity

Activity

Activity Raw

6.2% inhibition at 10-3M

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line CaCo-2

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 25 Activity

Activity

Activity Raw

21.2% inhibition at 10-3M

Detail Source Activity Anticancer

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT/MTS assay

Testing Time 9.53-Min

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006