TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB43307

Peptide_Name

IVO-24

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

YPHYSLPGSSTL

FASTA

>TPDB43307|Anticancer;Tumor-homing Peptides|length=12
YPHYSLPGSSTL

Formula C61H88N14O19

Absent Amino Acids ARNDCEQIKMFWV

Common Amino Acids S

Mass 1321.45

PI 7.71

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +0

Boman Index -0.60

Hydrophobicity -0.408

Aliphatic Index 65.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 225.51

Polar Residues 6

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

1

H

0

I

2

L

0

K

0

M

0

F

2

P

3

S

1

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 2 K: 0 M: 0 F: 0 P: 2 S: 3 T: 1 W: 0 Y: 2 V: 0

Length

12

Formula

C61H88N14O19

Mass

1321.45

PI

7.71

Net Charge

+0

Boman Index

-0.60

Hydrophobicity

-0.408

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell

Homing or Targeting Homing

Target Tumor Multiple tumor

Receptors Biomarker VEGF

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Antiangiogenic targeting liposomes increase therapeutic efficacy for solid tumors

Year 2009

Reference

Chang DK et al. J Biol Chem. 2009 May 8 284(19):12905-16.

Patent US 7,704,953 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo

SAS (oral cancer), HCT116 (colon cancer), BT483 (breast cancer),Mahlavu (liver cancer),PaCa-2 (pancreatic cancer) ,VEGF-stimulated HUVEC(mimic of angiogenic endothelial cells,surgical samples of human breast cancer

InVivo Model SCID mice

Source Type Phage display library

Phage Display Library M13 phage/15 mer peptide library

Conjugate Payload Liposomal doxorubicin

Conjugate_Payload

Liposomal doxorubicin

InVitro_ExVivo

SAS (oral cancer), HCT116 (colon cancer), BT483 (breast cancer),Mahlavu (liver cancer),PaCa-2 (pancreatic cancer) ,VEGF-stimulated HUVEC(mimic of angiogenic endothelial cells,surgical samples of human breast cancer

InVivo_Model

SCID mice

Phage_Display_Library

M13 phage/15 mer peptide library