TPDB

3D PDB MODEL

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TPDB ID TPDB43301

Peptide_Name

Clone 6(50)

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

YIHYIF

FASTA

>TPDB43301|Anticancer;Tumor-homing Peptides|length=6
YIHYIF

Formula C45H58N8O9

Absent Amino Acids ARNDCEQGLKMPSTWV

Common Amino Acids IY

Mass 855.00

PI 7.71

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +0

Boman Index -2.67

Hydrophobicity 1.000

Aliphatic Index 130.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 348.54

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

2

I

0

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

6

Formula

C45H58N8O9

Mass

855.00

PI

7.71

Net Charge

+0

Boman Index

-2.67

Hydrophobicity

1.000

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Plasma cell

Homing or Targeting Targeting

Target Tumor Multiple myeloma

Receptors Biomarker M-protein

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Identification of patient-specific peptides for detection of M-proteins and myeloma cells

Year 1999

Reference

Szecsi PB et al. Br J Haematol. 1999 Nov 107(2):357-64.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo ELISA ASSAY on patients serum

Source Type Phage display library

Phage Display Library M13 phage/ Random 6-mer peptide library & M13 phage/ 15-mer peptide library.

Conjugate Payload FITC, Cy3 goat antihuman immunoglobin

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor multiple myeloma

Receptors Biomarker M-protein

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria

Year 2022

Reference

US 11219671 B1

Patent US 11219671 B1

Other

InVivo Model Salmonella typhimurium

Source Type Phage display library

Phage Display Library Ph.D-7 Phage Display

Conjugate_Payload

FITC, Cy3 goat antihuman immunoglobin

InVitro_ExVivo

ELISA ASSAY on patients serum

InVivo_Model

Salmonella typhimurium

Phage_Display_Library

M13 phage/ Random 6-mer peptide library & M13 phage/ 15-mer peptide library. Ph.D-7 Phage Display