TPDB

3D PDB MODEL

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TPDB ID TPDB43288

Peptide_Name

YR13 peptide

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Modification

N-terminal: N -terminal Iodination

Sequence

YEDIKPKTSLAFR

FASTA

>TPDB43288|Anticancer;Tumor-homing Peptides|length=13
YEDIKPKTSLAFR

Formula C72H114N18O21

Absent Amino Acids NCQGHMWV

Common Amino Acids K

Mass 1567.81

PI 9.65

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 5

Net Charge +1

Boman Index 3.65

Hydrophobicity -0.831

Aliphatic Index 67.69

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 95.04

Polar Residues 3

number

1

A

1

R

0

N

1

D

0

C

1

E

0

Q

0

G

0

H

1

I

1

L

2

K

0

M

1

F

1

P

1

S

1

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 1 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 0

Length

13

Formula

C72H114N18O21

Mass

1567.81

PI

9.65

Net Charge

+1

Boman Index

3.65

Hydrophobicity

-0.831

N_terminal_Modification

N -terminal Iodination

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Target Tumor Human nasopharyngeal carcinoma

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Radiolabeling and biodistribution of a nasopharyngeal carcinoma-targeting peptide identified by in vivo phage display

Year 2009

Reference

SUN L et al. Acta Biochim Biophys Sin (Shanghai). 2007 Aug 39(8):624-32.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo CEN-1 human nasopharyngeal carcinoma (NPC)

InVivo Model Athymic nude mice at 4-6 weeks of age were injectedsubcutaneously in the right flank with CNE-1 human NPC

Source Type Phage display library

Phage Display Library M13 phage /12 mer peptide library

Conjugate Payload Iodine132

Conjugate_Payload

Iodine132

InVitro_ExVivo

CEN-1 human nasopharyngeal carcinoma (NPC)

InVivo_Model

Athymic nude mice at 4-6 weeks of age were injectedsubcutaneously in the right flank with CNE-1 human NPC

Phage_Display_Library

M13 phage /12 mer peptide library