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Peptide record

TPDB43218

Cyclic [W(RW)4 ]-Dox Anticancer standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB43218
Cyclic [W(RW)4 ]-Dox
Anticancer
Cancer-related peptides
CancerPPD 2.0 Peptipedia SATPdb dbACP
standard
No
A 9-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
Chemical: Doxorubicin (Dox) which is anthracycline attached with linker to CPP [W(RW)4 ]
Sequence
WRWRWRWRW
Physicochemical Analysis
C79H100N26O10
ANDCEQGHILKMFPSTYV
W
1573.83
12.88
4
0
5
+4
-6.01
-2.500
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
27500
1747.33
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
9
C79H100N26O10
1573.83
12.88
+4
-6.01
-2.500
Free
Doxorubicin (Dox) which is anthracycline attached with linker to CPP [W(RW)4 ]
L
Cyclic
Free
Anticancer
Doxorubicin (Dox) is a well-known anthracycline which has been conjugated to a CPP
Evidence Records 4 records
Evidence 1 Activity

Activity

62-73% inhibition of cell proliferation at 1 µM
Anticancer

Target

Leukemia Cancer
CCRF-CEM
Blood

Assay & Model

MTT/MTS assay
72 to 120-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

51-74% inhibition of cell proliferation at 1 µM
Anticancer

Target

Ovarian Cancer
SK-OV-3
Ovary

Assay & Model

MTT/MTS assay
72 to 120-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013
Evidence 3 Activity

Activity

50-67% inhibition of cell proliferation at 1 µM
Anticancer

Target

Colon Cancer
HCT-116
Colon

Assay & Model

MTT/MTS assay
72 to 120-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013
Evidence 4 Activity

Activity

60-79% inhibition of cell proliferation at 1 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
72 to 120-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013