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Peptide record

TPDB43205

PC5-54 Anticancer Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB43205
PC5-54
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
WPLHTSVYPPSP
Physicochemical Analysis
C67H93N15O17
ARNDCEQGIKMF
P
1380.57
7.77
1
0
4
+0
-0.12
-0.508
56.67
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
6990
506.31
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
1
L
0
K
0
M
0
F
4
P
2
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 4 S: 2 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
12
C67H93N15O17
1380.57
7.77
+0
-0.12
-0.508
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Lung cancer
Integrins, Alpha-5 beta-3 and Alpha-5 beta-5

Source & Reference

TumorHoPe2.0
TumorHoPe2
Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery
2007
Lee TY et al. Cancer Res. 2007 Nov 15 67(22):10958-65.
US 2008/0193510A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
Phage display library
M13 phage/random peptide library
Additional Detail Fields 3 fields
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
M13 phage/random peptide library