TPDB

3D PDB MODEL

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TPDB ID TPDB43204

Peptide_Name

Ph12-1

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

WNLPWYYSVSPT

FASTA

>TPDB43204|Anticancer;Tumor-homing Peptides|length=12
WNLPWYYSVSPT

Formula C75H97N15O19

Absent Amino Acids ARDCEQGHIKMF

Common Amino Acids PSWY

Mass 1512.68

PI 5.88

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 6

Net Charge -0

Boman Index -4.35

Hydrophobicity -0.450

Aliphatic Index 56.67

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 13980

Absorbance 280nm 924.18

Polar Residues 6

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

2

P

2

S

1

T

2

W

2

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 2 T: 1 W: 2 Y: 2 V: 1

Length

12

Formula

C75H97N15O19

Mass

1512.68

PI

5.88

Net Charge

-0

Boman Index

-4.35

Hydrophobicity

-0.450

Motif

LTVXPW

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Targeting

Target Tumor Breast cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Identification of novel carrier peptides for the specific delivery of therapeutics into cancer cells

Year 2002

Reference

Shadidi M et al. FASEB J. 2003 Feb 17(2):256-8.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo The breast cancer cell lines SK-BR-3, T47D, MCF-7, PM-, colon cancer cell line HT2933,prostate cancer cell line DU145 lung cancer cell line DMS-273,U87MG cell line,

Source Type Phage display library

Phage Display Library M13 phage/ 12 mer peptide library&M13 phage/7 mer peptide library

Conjugate Payload GFP & 6-iodoacetamido

Conjugate_Payload

GFP & 6-iodoacetamido

InVitro_ExVivo

The breast cancer cell lines SK-BR-3, T47D, MCF-7, PM-, colon cancer cell line HT2933,prostate cancer cell line DU145 lung cancer cell line DMS-273,U87MG cell line,

Phage_Display_Library

M13 phage/ 12 mer peptide library&M13 phage/7 mer peptide library