TPDB

3D PDB MODEL

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TPDB ID TPDB43180

Peptide_Name

Peptide13 Gonearrestide

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

WCYKLPDRVSIKEKGRCN-NH2

FASTA

>TPDB43180|Anticancer|length=18
WCYKLPDRVSIKEKGRCN-NH2

Formula C96H155N29O26S2

Absent Amino Acids AQHMFT

Common Amino Acids K

Mass 2195.59

PI 9.63

Basic Residues 5

Acidic Residues 2

Hydrophobic Residues 5

Net Charge +3

Boman Index 4.78

Hydrophobicity -1.039

Aliphatic Index 59.44

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 7115

Absorbance 280nm 324.06

Polar Residues 5

number

0

A

2

R

1

N

1

D

2

C

1

E

0

Q

1

G

0

H

1

I

1

L

3

K

0

M

0

F

1

P

1

S

0

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 2 N: 1 D: 1 C: 2 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 3 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 1

Length

18

Formula

C96H155N29O26S2

Mass

2195.59

PI

9.63

Net Charge

+3

Boman Index

4.78

Hydrophobicity

-1.039

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Anticancer

Origin

Androctonus mauritanicus

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 ~ 100 µM/L

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Colon Cancer

Cell Line HCT-116

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2018

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line DLD-1

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2018

Evidence 3 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line HKe-3

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2018

Evidence 4 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Colon Cancer

Cell Line Dks8

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2018

Evidence 5 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Brain tumor

Cell Line U-251

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2018