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Peptide record

TPDB43163

Anticancer Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB43163
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
VSFLEYR
Physicochemical Analysis
C43H64N10O12
ANDCQGHIKMPTW
RELFSYV
913.04
6.90
1
1
4
-0
0.40
0.100
97.14
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
163.19
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
7
C43H64N10O12
913.04
6.90
-0
0.40
0.100
Evidence Records 4 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Homing (Phage display clone)
Prostrate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeting the prostate for destruction through a vascular address
2002
Arap W et al. Proc Natl Acad Sci U S A. 2002 Feb 5 99(3):1527-31.
US 6,232,287 B1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
CD-1 male mice(2-4 months)
Phage display library
T7,fUSE5 phage /7mer peptide library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
Prostate cancer
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor vasculature
Targeting
Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria
2022
US 11219671 B1
US 11219671 B1

Other

Salmonella typhimurium
Phage display library
Ph.D-7 Phage Display
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing
Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Additional Detail Fields 4 fields
Nanoworms(NWs), polyethylene glycol nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
CD-1 male mice(2-4 months) Athymic nude mice, ApoE null mice Salmonella typhimurium BALB/c athymic nude mice
T7,fUSE5 phage /7mer peptide library T7 phage / cyclic Cx7C and linear X7 peptide library Ph.D-7 Phage Display T7 phage display library