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Peptide record

TPDB43151

LL-III/24 Anticancer Antifungal modified_plain modified
15 amino acids
Basic Information
3D PDB MODEL
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TPDB43151
LL-III/24
Anticancer Antifungal
Anti-infective peptides Cancer-related peptides
CancerPPD 2.0 Peptipedia SATPdb dbACP CAFPdb
modified_plain
Yes
A 15-aa modified multi-activity (Anticancer and Antifungal) peptide sequence curated from CancerPPD 2.0, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: O = Ornithine
Sequence
VNWOOILGOIIOVVO-NH2
Physicochemical Analysis
C56H92N12O12
ARDCEQHKMFPSTY
IV
1125.42
6.02
0
0
8
-0
-2.70
1.673
162.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
488.71
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
15
C56H92N12O12
1125.42
6.02
-0
-2.70
1.673
Amidation
O = Ornithine
L
Linear
Free
Antimicrobial and Antifungal
Lasioglossin III and its analogs
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
IC50 = 3±1 µM
Anticancer
3

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT/MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 20 µM
Anticancer
20 µM

Target

Colon Cancer
SW
Colon

Assay & Model

MTT/MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012
Evidence 3 Activity

Activity

IC50
IC50 = 5±2 µM
Anticancer
5

Target

Leukemia Cancer
CCRF-CEM
Blood

Assay & Model

MTT/MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012