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Peptide record

TPDB43142

B1-Leu Anticancer Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB43142
B1-Leu
Anticancer Cell-penetrating Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 15-aa standard natural multi-activity (Anticancer and Cell-penetrating Peptides) peptide sequence curated from CancerPPD 2.0, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
VKRFKKFFRKLKKLV-NH2
Physicochemical Analysis
C97H165N27O16
ANDCEQGHIMPSTWY
K
1965.55
12.46
8
0
7
+8
3.19
-0.533
90.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
6
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 6 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
15
C97H165N27O16
1965.55
12.46
+8
3.19
-0.533
Amidation
L
Linear
Linear
Free
Antimicrobial and Anticancer
Synthetic analog of B1
N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
IC50 = 3.6 µM
Anticancer
3.6 µM

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 1.1 µM
Anticancer
1.1 µM

Target

Leukemia cancer
K-562
Blood

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 3 Activity

Activity

IC50
IC50 = 4.4 µM
Anticancer
4.4 µM

Target

Breast Cancer
MCF-7/ADM
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 4 Activity

Activity

IC50
IC50 = 3.3 µM
Anticancer
3.3 µM

Target

Leukemia cancer
K-562/ADM
Blood

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
In vitro
CTTTHHHHHHHTTTC
Additional Detail Fields 1 fields
CTTTHHHHHHHTTTC