TPDB

3D PDB MODEL

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TPDB ID TPDB43123

Peptide_Name

ACE inhibitor

Activity

Anticancer Antihypertensive

Activity_category_statistics

Cardiometabolic peptides Cancer-related peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural multi-activity (Anticancer and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

VENLHLPLPLL

FASTA

>TPDB43123|Anticancer;Antihypertensive|length=11
VENLHLPLPLL

Formula C60H100N14O15

Absent Amino Acids ARDCQGIKMFSTWY

Common Amino Acids L

Mass 1257.54

PI 5.13

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 6

Net Charge -1

Boman Index 1.57

Hydrophobicity 0.891

Aliphatic Index 203.64

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

1

N

0

D

0

C

1

E

0

Q

0

G

1

H

0

I

5

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 5 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

11

Formula

C60H100N14O15

Mass

1257.54

PI

5.13

Net Charge

-1

Boman Index

1.57

Hydrophobicity

0.891

Chemical_Mass

1257.5168

Monoisotopic_Mass

1256.7469

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 175.00 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Robert M. C., Razaname A., Mutter M., Juillerat M. A.

Title

Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765. J. Agric. Food. Chem., 52, 6923-6931, 2004

Year 2004

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 11

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C60H100N14O15/c1-30(2)21-38(66-54(82)41(27-47(61)75)68-50(78)37(17-18-48(76)77)65-57(85)49(62)35(11)12)51(79)67-40(26-36-28-63-29-64-36)53(81)70-42(23-32(5)6)58(86)74-20-14-16-46(74)56(84)71-43(24-33(7)8)59(87)73-19-13-15-45(73)55(83)69-39(22-31(3)4)52(80)72-44(60(88)89)25-34(9)10/h28-35,37-46,49H,13-27,62H2,1-12H3,(H2,61,75)(H,63,64)(H,65,85)(H,66,82)(H,67,79)(H,68,78)(H,69,83)(H,70,81)(H,71,84)(H,72,80)(H,76,77)(H,88,89)/t37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,49-/m0/s1 InChIKey=DBHLZNQDTOOIDF-PTPXOIFGSA-N Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8317), the DFBP database

Number_of_Residues

11