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Peptide record

TPDB43094

Loop2-PS2Aa Anticancer standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB43094
Loop2-PS2Aa
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 12-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
TYFNAVKPPITA-NH2
Physicochemical Analysis
C63H96N14O17
RDCEQGHLMSW
APT
1321.54
9.74
1
0
6
+1
-0.06
0.150
73.33
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
112.75
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
1
K
0
M
1
F
2
P
0
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 2 S: 0 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
12
C63H96N14O17
1321.54
9.74
+1
-0.06
0.150
Amidation
L
Linear
Free
Anticancer
Parasporin-2Aa1
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
EC50 = 92.99 ± 0.98 µM
Anticancer
92.99

Target

Colorectal Cancer
SW-480
Colon

Assay & Model

Sulforhodamine B assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

EC50
EC50 = 15.95 ± 0.69 µM
Anticancer
15.95

Target

Colorectal Cancer
SW-620
Colon

Assay & Model

Sulforhodamine B assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021