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Peptide record

TPDB43084

HN1-PKC(Synthetic) HN1 Anticancer Cell-penetrating Peptides Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB43084
HN1-PKC(Synthetic) HN1
Anticancer Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP StackTHP StackTHPred TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Anticancer, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, CellPPD, CellPPD-MOD, and other sources, with an available 3D structural model.
Sequence
TSPLNIHNGQKL
Physicochemical Analysis
C57H96N18O18
ARDCEMFWYV
NL
1321.50
10.10
2
0
3
+1
2.67
-0.750
97.50
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
0
A
0
R
2
N
0
D
0
C
0
E
1
Q
1
G
1
H
1
I
2
L
1
K
0
M
0
F
1
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 2 K: 1 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C57H96N18O18
1321.50
10.10
+1
2.67
-0.750
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Homing
Head and neck squamous cell carcinoma (HNSCC)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer
2009
Bao L et al. Cancer Res. 2009 Jul 15 69(14):5829-34.
US 2002/0102265A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
UMSCC1 (HNSCC cell lines), UMSCC36 cells (HNSCC cell lines), normal oral epithelial cells (E6/E7-NOE)
Athymic nude mice
Synthetic
FITC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Additional Detail Fields 3 fields
FITC necrosis-inducing peptide, Fluorescein (FAM)
UMSCC1 (HNSCC cell lines), UMSCC36 cells (HNSCC cell lines), normal oral epithelial cells (E6/E7-NOE) Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
Athymic nude mice 6-week-old BalB/C mice