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Peptide record

TPDB43028

Anticancer Tumor-homing Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB43028
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 10-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
TAASGVRSMH
Physicochemical Analysis
C40H69N15O14S1
NDCEQILKFPWY
AS
1016.14
11.05
2
0
4
+1
1.68
-0.070
49.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
0
L
0
K
1
M
0
F
0
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 1 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
10
C40H69N15O14S1
1016.14
11.05
+1
1.68
-0.070
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell and angiogenic tumor vasculature
Homing
Melanoma
Proteoglycan

Source & Reference

TumorHoPe2.0
TumorHoPe2
NG2 proteoglycan-binding peptides target tumor neovasculature
1999
Burg MA et al. Cancer Res. 1999 Jun 15 59(12):2869-74.
US 6,528,481 B1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
NG2 fragments (transfected human embryonic kidney 293 cells )
NG2 knockout mice, NG2 expressing wild mice.
Phage display library
Phage/linear 10 mer peptide library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Human Melanoma
MERTK, BRAF V600E

Source & Reference

TumorHoPe2.0
TumorHoPe2
Molecular dynamics, MMGBSA, and docking studies of natural products conjugated to tumor-targeted peptide for targeting BRAF V600E and MERTK receptors
2023
J Lambo D et al. Mol Divers. 2023 Feb 27(1):389-423.

Other

Synthetic
Thiazole-2-carboxylic acid, Cinnamic acid, Theanine, Protocatechuic acid
Additional Detail Fields 4 fields
Thiazole-2-carboxylic acid, Cinnamic acid, Theanine, Protocatechuic acid
NG2 fragments (transfected human embryonic kidney 293 cells )
NG2 knockout mice, NG2 expressing wild mice.
Phage/linear 10 mer peptide library