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Peptide record

TPDB43022

L-SP5 PC3-4 SP5-52 A2 Anticancer Antiviral Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB43022
L-SP5 PC3-4 SP5-52 A2
Anticancer Antiviral Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides
Peptipedia AI4AVP DRAVP 2.0 StackTHP StackTHPred TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Anticancer, Antiviral, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, AI4AVP, DRAVP 2.0, and other sources, with an available 3D structural model.
Sequence
SVSVGMKPSPRP
Physicochemical Analysis
C53H92N16O16S1
ANDCEQHILFTWY
PS
1241.47
11.49
2
0
3
+2
3.46
-0.475
48.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
1
M
0
F
3
P
3
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 1 F: 0 P: 3 S: 3 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
12
C53H92N16O16S1
1241.47
11.49
+2
3.46
-0.475
WTYY
Evidence Records 4 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Targeting
Lung cancer, non-small cell lung cancer (NSCLC)

Source & Reference

TumorHoPe2.0
TumorHoPe2
A Novel Peptide Enhances Therapeutic Efficacy of Liposomal Anti-Cancer Drugs in Mice Models of Human Lung Cancer
2009
Chang DK et al. PLoS One. 2009 4(1):e4171.
US 2008/0193375A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
CL1-5, PC13, Specimens of pulmonary adenocarcinoma
Phage display library
M15 phage /random peptide library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Cancer stem cell
Homing
Human Glioblastoma multiforme
U87R

Source & Reference

TumorHoPe2.0
TumorHoPe2
Brain tumor targeting peptides and methods
2013
US 8530429 B2
US 8530429 B2

Other

U87-MG cell line
SCID mice
Phage display library
PhD-12 M13 combinatorial phage display library
radio-imaging
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Targeting

Source & Reference

TumorHoPe2.0
TumorHoPe2
2013
Ying Li et al. Bioconjug Chem. 2013 Jan 16 24(1):133-43.

Other

KB, U87, SGC, HUVEC tumor cell line
PEG-DSPE micelles
Additional Detail Fields 4 fields
necrosis-inducing peptide, Fluorescein (FAM) radio-imaging PEG-DSPE micelles
CL1-5, PC13, Specimens of pulmonary adenocarcinoma Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line U87-MG cell line KB, U87, SGC, HUVEC tumor cell line
6-week-old BalB/C mice SCID mice
M15 phage /random peptide library PhD-12 M13 combinatorial phage display library