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Peptide record

TPDB43014

Clone PC5-4 Anticancer Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB43014
Clone PC5-4
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
STLPPPLRFANV
Physicochemical Analysis
C61H98N16O16
DCEQGHIKMWY
P
1311.55
11.05
1
0
5
+1
0.50
0.175
97.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
1
F
3
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 3 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C61H98N16O16
1311.55
11.05
+1
0.50
0.175
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing (Phage display clone)
Lung cancer
Integrins, Alpha-5 beta-3 and Alpha-5 beta-5

Source & Reference

TumorHoPe2.0
TumorHoPe2
Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery
2007
Lee TY et al. Cancer Res. 2007 Nov 15 67(22):10958-65.
US 2008/0193510A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
Phage display library
M13 phage/random peptide library
Additional Detail Fields 3 fields
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
M13 phage/random peptide library