TPDB

3D PDB MODEL

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TPDB ID TPDB42967

Peptide_Name

IVO-8

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

SNPFSKPYGLTV

FASTA

>TPDB42967|Anticancer;Tumor-homing Peptides|length=12
SNPFSKPYGLTV

Formula C61H92N14O18

Absent Amino Acids ARDCEQHIMW

Common Amino Acids PS

Mass 1309.48

PI 9.74

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index 0.16

Hydrophobicity -0.317

Aliphatic Index 56.67

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 113.79

Polar Residues 5

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

1

K

0

M

1

F

2

P

2

S

1

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 1 P: 2 S: 2 T: 1 W: 0 Y: 1 V: 1

Length

12

Formula

C61H92N14O18

Mass

1309.48

PI

9.74

Net Charge

+1

Boman Index

0.16

Hydrophobicity

-0.317

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell

Homing or Targeting Homing

Target Tumor Multiple tumor

Receptors Biomarker VEGF

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Antiangiogenic targeting liposomes increase therapeutic efficacy for solid tumors

Year 2009

Reference

Chang DK et al. J Biol Chem. 2009 May 8 284(19):12905-16.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo

SAS (oral cancer), HCT116 (colon cancer), BT483 (breast cancer), Mahlavu (liver cancer),PaCa-2 (pancreatic cancer) ,VEGF-stimulated HUVEC (mimic of angiogenic endothelial cells, surgical samples of human breast cancer

InVivo Model SCID mice

Source Type Phage display library

Phage Display Library M13 phage/15 mer peptide library

Conjugate Payload Liposomal doxorubicin

Conjugate_Payload

Liposomal doxorubicin

InVitro_ExVivo

SAS (oral cancer), HCT116 (colon cancer), BT483 (breast cancer), Mahlavu (liver cancer),PaCa-2 (pancreatic cancer) ,VEGF-stimulated HUVEC (mimic of angiogenic endothelial cells, surgical samples of human breast cancer

InVivo_Model

SCID mice

Phage_Display_Library

M13 phage/15 mer peptide library