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Peptide record

TPDB42962

Chimeric SMSIARL-GG-D(KLAKLAK)2 Anticancer Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB42962
Chimeric SMSIARL-GG-D(KLAKLAK)2
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
SMSIARL
Physicochemical Analysis
C32H60N10O10S1
NDCEQGHKFPTWYV
S
776.95
11.05
1
0
4
+1
-0.20
0.843
125.71
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
1
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 1 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C32H60N10O10S1
776.95
11.05
+1
-0.20
0.843
Evidence Records 4 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Angiogenic endothelial cell
Homing
Prostrate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeting the prostate for destruction through a vascular address
2002
Arap W et al. Proc Natl Acad Sci U S A. 2002 Feb 5 99(3):1527-31.
US 2001/0046498 A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
TRAMP (prostate cancer-prone transgenic mice),CD-1 male mice (2-4 months)
Phage display library
T7,fUSE5 phage /7mer peptide library
Proapoptotic peptide (KLAKLAK)2
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
Prostate cancer
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor vasculature
Targeting
Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria
2022
US 11219671 B1
US 11219671 B1

Other

Salmonella typhimurium
Phage display library
Ph.D-7 Phage Display
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing
Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Additional Detail Fields 4 fields
Proapoptotic peptide (KLAKLAK)2 Nanoworms(NWs), polyethylene glycol nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
TRAMP (prostate cancer-prone transgenic mice),CD-1 male mice (2-4 months) Athymic nude mice, ApoE null mice Salmonella typhimurium BALB/c athymic nude mice
T7,fUSE5 phage /7mer peptide library T7 phage / cyclic Cx7C and linear X7 peptide library Ph.D-7 Phage Display T7 phage display library