TPDB

3D PDB MODEL

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TPDB ID TPDB42961

Peptide_Name

Phage 7

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

SMPINSPYIPWS

FASTA

>TPDB42961|Anticancer;Tumor-homing Peptides|length=12
SMPINSPYIPWS

Formula C65H94N14O18S1

Absent Amino Acids ARDCEQGHLKFTV

Common Amino Acids PS

Mass 1391.60

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 5

Net Charge -0

Boman Index -1.48

Hydrophobicity -0.167

Aliphatic Index 65.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 502.30

Polar Residues 5

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

0

G

0

H

2

I

0

L

0

K

1

M

0

F

3

P

3

S

0

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 1 F: 0 P: 3 S: 3 T: 0 W: 1 Y: 1 V: 0

Length

12

Formula

C65H94N14O18S1

Mass

1391.60

PI

5.94

Net Charge

-0

Boman Index

-1.48

Hydrophobicity

-0.167

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing (Phage display clone)

Target Tumor Gastric cancer, Liver metastassis

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential

Year 2006

Reference

Hu S et al. Biochem Biophys Res Commun. 2006 Mar 24 341(4):964-72.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo Human gastric cancer cell line XGC9811, XGC9811(liver metastatic gastric cell line) LAGS, MKN45

InVivo Model BALB/c nude mice( 4- to 5-weeks-old) bearing human gastric carcinoma cell line XGC9811 xenograft

Source Type Phage display library

Phage Display Library M13PIII phage/12 mer random peptide library

InVitro_ExVivo

Human gastric cancer cell line XGC9811, XGC9811(liver metastatic gastric cell line) LAGS, MKN45

InVivo_Model

BALB/c nude mice( 4- to 5-weeks-old) bearing human gastric carcinoma cell line XGC9811 xenograft

Phage_Display_Library

M13PIII phage/12 mer random peptide library