TPDB

3D PDB MODEL

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TPDB ID TPDB42950

Peptide_Name

Soybean lunasin anti-inflammatory peptide

Activity

Anti-inflammatory Anticancer Antifungal

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides

Database_Source

Peptipedia SATPdb dbACP Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 43-aa standard natural multi-activity (Anti-inflammatory, Anticancer, and Antifungal) peptide sequence curated from Peptipedia, SATPdb, dbACP, and other sources, with an available 3D structural model.

Sequence

SKWQHQQDSCRKQLQGVNLTPCEKHIMEKIQGRGDDDDDDDDD

FASTA

>TPDB42950|Anti-inflammatory;Anticancer;Antifungal|length=43
SKWQHQQDSCRKQLQGVNLTPCEKHIMEKIQGRGDDDDDDDDD

Formula C204H321N65O78S3

Absent Amino Acids AFY

Common Amino Acids D

Mass 5028.36

PI 4.23

Basic Residues 8

Acidic Residues 12

Hydrophobic Residues 7

Net Charge -6

Boman Index 24.39

Hydrophobicity -1.763

Aliphatic Index 43.02

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5625

Absorbance 280nm 111.87

Polar Residues 12

number

0

A

2

R

1

N

10

D

2

C

2

E

6

Q

3

G

2

H

2

I

2

L

4

K

1

M

0

F

1

P

2

S

1

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 2 N: 1 D: 10 C: 2 E: 2 Q: 6 G: 3 H: 2 I: 2 L: 2 K: 4 M: 1 F: 0 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 1

Length

43

Formula

C204H321N65O78S3

Mass

5028.36

PI

4.23

Net Charge

-6

Boman Index

24.39

Hydrophobicity

-1.763

Chemical_Mass

5028.3057

Monoisotopic_Mass

5025.2238

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Function Anti-inflammatory

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Gonzalez de Mejia E., Dia V. P.

Title

Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-κB pathway in the macrophage. Peptides, 30, 2388-2398, 2009

Year 2009

Literature Source Journal

Other

Number of Residues 43

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC3=C[N]([H])C=N3)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](O)C)C(=O)N4[C@@H](CCC4)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC5=C[N]([H])C=N5)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O InChI=1S/C204H321N65O78S3/c1-13-93(9)160(199(343)245-109(38-46-138(211)274)166(310)227-81-144(280)231-102(34-25-58-223-203(217)218)164(308)226-82-145(281)232-123(68-149(287)288)183(327)253-124(69-150(289)290)184(328)254-125(70-151(291)292)185(329)255-126(71-152(293)294)186(330)256-127(72-153(295)296)187(331)257-128(73-154(297)298)188(332)258-129(74-155(299)300)189(333)259-130(75-156(301)302)190(334)261-132(202(346)347)77-158(305)306)266-178(322)106(33-20-24-57-208)236-172(316)114(43-51-147(283)284)241-177(321)116(53-61-350-12)246-200(344)161(94(10)14-2)267-193(337)121(66-98-80-222-89-230-98)251-170(314)105(32-19-23-56-207)235-173(317)115(44-52-148(285)286)244-196(340)135(87-349)264-197(341)136-36-27-60-269(136)201(345)162(95(11)272)268-192(336)118(63-91(5)6)248-182(326)122(67-143(216)279)260-198(342)159(92(7)8)265-146(282)83-228-165(309)108(37-45-137(210)273)238-179(323)117(62-90(3)4)247-174(318)111(40-48-140(213)276)239-167(311)104(31-18-22-55-206)234-168(312)107(35-26-59-224-204(219)220)237-195(339)134(86-348)263-194(338)133(85-271)262-191(335)131(76-157(303)304)252-176(320)112(41-49-141(214)277)240-171(315)110(39-47-139(212)275)243-181(325)120(65-97-79-221-88-229-97)250-175(319)113(42-50-142(215)278)242-180(324)119(64-96-78-225-101-29-16-15-28-99(96)101)249-169(313)103(30-17-21-54-205)233-163(307)100(209)84-270/h15-16,28-29,78-80,88-95,100,102-136,159-162,225,270-272,348-349H,13-14,17-27,30-77,81-87,205-209H2,1-12H3,(H2,210,273)(H2,211,274)(H2,212,275)(H2,213,276)(H2,214,277)(H2,215,278)(H2,216,279)(H,221,229)(H,222,230)(H,226,308)(H,227,310)(H,228,309)(H,231,280)(H,232,281)(H,233,307)(H,234,312)(H,235,317)(H,236,316)(H,237,339)(H,238,323)(H,239,311)(H,240,315)(H,241,321)(H,242,324)(H,243,325)(H,244,340)(H,245,343)(H,246,344)(H,247,318)(H,248,326)(H,249,313)(H,250,319)(H,251,314)(H,252,320)(H,253,327)(H,254,328)(H,255,329)(H,256,330)(H,257,331)(H,258,332)(H,259,333)(H,260,342)(H,261,334)(H,262,335)(H,263,338)(H,264,341)(H,265,282)(H,266,322)(H,267,337)(H,268,336)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H,293,294)(H,295,296)(H,297,298)(H,299,300)(H,301,302)(H,303,304)(H,305,306)(H,346,347)(H4,217,218,223)(H4,219,220,224)/t93-,94-,95+,100-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,159-,160-,161-,162-/m0/s1 InChIKey=GXMLUULMDUFVAH-ASPFZTNWSA-N Review concerning Lunasin: Hsieh C.-C., Martínez-Villaluenga C., de Lumen B. O., Hernández-Ledesma B., 2018, Updating the research on the chemopreventive and therapeutic role of the peptide lunasin. J. Sci. Food Agric., 98, 2070–2079 Anticancer peptide according to the APD database the BIOPEP-UWM database of bioactive peptides (ID 9525) the EROP-Moscow database Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10124)

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Also showed anti-oxidant and anti-inflammatory activity ( Ren et al., 2018 ). Found also in barley and wheat. Found in multiple species. Updated 11/2023

Number_of_Residues

43