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Peptide record

TPDB42906

ATRA1-R3W2 - HYD Anticancer standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB42906
ATRA1-R3W2 - HYD
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 21-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
RRWKRFFKRWKGGVIGVTFPF-NH2
Physicochemical Analysis
C131H194N38O23
ANDCEQHLMSY
RF
2669.22
12.88
7
0
9
+7
-1.56
-0.519
46.19
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
412.11
1
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
0
L
3
K
0
M
4
F
1
P
0
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 0 K: 3 M: 0 F: 4 P: 1 S: 0 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
21
C131H194N38O23
2669.22
12.88
+7
-1.56
-0.519
Amidation
L
Linear
Free
Antimicrobial and Anticancer
Synthetic
Evidence Records 1 records
Evidence 1 Activity

Activity

LD50
LD50 ~24.5 µM
Anticancer
24.5 µM

Target

Lung Cancer
H-358
Lung

Assay & Model

Cytotoxicity assay
6-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
US011447533B2

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.