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Peptide record

TPDB42903

R11-NLS-pep8 Anticancer Cell-penetrating Peptides standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB42903
R11-NLS-pep8
Anticancer Cell-penetrating Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 CPPsite3.0
standard
No
A 38-aa standard natural multi-activity (Anticancer and Cell-penetrating Peptides) peptide sequence curated from CancerPPD 2.0 and CPPsite3.0, with an available 3D structural model.
N-terminal: Acetylation
Sequence
Ac-RRRRRRRRRRRIKKKRKWEASALVCIRLVTSSKPRTVA
Physicochemical Analysis
C203H374N86O46S1
NDQGHMFY
R
4787.81
12.97
19
1
11
+18
15.30
-1.453
71.84
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
114.88
6
Residue Composition
number
3
A
14
R
0
N
0
D
1
C
1
E
0
Q
0
G
0
H
2
I
2
L
5
K
0
M
0
F
1
P
3
S
2
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 14 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 5 M: 0 F: 0 P: 1 S: 3 T: 2 W: 1 Y: 0 V: 3
Chemical Descriptors
38
C203H374N86O46S1
4787.81
12.97
+18
15.30
-1.453
Free
L
Linear
Acetylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

4T1, B16-F0, A549, MDA-MB-23, Hepg2 And Panc-1 Cells

Assay & Model

Six- to eight-week-old C57BL/6 male and BALB/C female mice
Six- to eight-week-old C57BL/6 male and BALB/C female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
In vitro and in vivo
CCCGGGGGGGSCTTTCCCCCCCCCSCCCTTCCCCCCCC
Additional Detail Fields 1 fields
CCCGGGGGGGSCTTTCCCCCCCCCSCCCTTCCCCCCCC