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Peptide record

TPDB42877

Neurotensin NT-9 Anti-inflammatory Anticancer Neuropeptide Tumor-homing Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB42877
Neurotensin NT-9
Anti-inflammatory Anticancer Neuropeptide Tumor-homing Peptides
Cancer-related peptides Immunity and inflammation peptides Neuroactive peptides
Peptipedia CancerPPD 2.0 TumorHoPe2.0
standard
No
A 6-aa standard natural multi-activity (Anti-inflammatory, Anticancer, Neuropeptide, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and TumorHoPe2.0, with an available 3D structural model.
Sequence
RRPYIL
Physicochemical Analysis
C38H64N12O8
ANDCEQGHKMFSTWV
R
817.00
11.16
2
0
3
+2
0.26
-0.600
130.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
182.37
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
6
C38H64N12O8
817.00
11.16
+2
0.26
-0.600
Free
816.9878
L
Linear
816.4956
Free
Anticancer
Synthetic analogue of Neurotensin
Evidence Records 4 records
Evidence 1 Activity

Activity

EC50
Anti-inflammatory
0.00 µM
anti inflammatory
ai

Source & Reference

NA
Wei E. T., Thomas H. A.
Anti-inflammatory peptide agonists. Annu. Rev. Pharmacol. Toxicol., 33, 91-108
1993
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C38H64N12O8/c1-5-22(4)30(34(55)48-28(36(57)58)19-21(2)3)49-32(53)27(20-23-12-14-24(51)15-13-23)47-33(54)29-11-8-18-50(29)35(56)26(10-7-17-45-38(42)43)46-31(52)25(39)9-6-16-44-37(40)41/h12-15,21-22,25-30,51H,5-11,16-20,39H2,1-4H3,(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H,57,58)(H4,40,41,44)(H4,42,43,45)/t22-,25-,26-,27-,28-,29-,30-/m0/s1 InChIKey=DQDBCHHEIKQPJD-ODKJCKIQSA-N
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Colorectal Cancer
HCT-116
Colon

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2023

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Neurotensin
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell, Tumor cell, Tumor vessel
Targeting
Breast cancer, Colon cancer, Pancreatic ductal adenocarcinoma
NT

Source & Reference

TumorHoPe2.0
TumorHoPe2
Nano-enabled immunotherapy in cancer
2022
US 11433143 B2
US 11433143 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell
BALB/c mice
Phage display library
PEGylated cholesterol , indoximod
Additional Detail Fields 5 fields
PEGylated cholesterol , indoximod
Neurotensin
4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell
BALB/c mice
6