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Peptide record

TPDB42865

IDP-La05 Anticancer standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB42865
IDP-La05
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 17-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
Chemical: -(CH2)6-CH=CH-(CH2)3 Chemical: a biradical linker links R(8) and Q(15)
Sequence
RRNDLRSRFLALRDQVP
Physicochemical Analysis
C90H154N34O25
CEGHIKMTWY
R
2112.43
12.22
5
2
6
+3
5.18
-1.100
91.76
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
5
R
1
N
2
D
0
C
0
E
1
Q
0
G
0
H
0
I
3
L
0
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 2 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 3 K: 0 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C90H154N34O25
2112.43
12.22
+3
5.18
-1.100
Free
-(CH2)6-CH=CH-(CH2)3 a biradical linker links R(8) and Q(15)
L
Linear
Free
Anticancer
Synthetic
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
EC50 ~ 22.5 µM
Anticancer
22.5 µM

Target

Lung Cancer
NCl-H187
Lung

Assay & Model

MTT/Alamamar-Blue/Hexosaminidase activity test
48-72 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
US20200239547A1

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

EC50
EC50 ~ 15 µM
Anticancer
15 µM

Target

Lung Cancer
NCl-H82
Lung

Assay & Model

MTT/Alamamar-Blue/Hexosaminidase activity test
48-72 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
US20200239547A1
Evidence 3 Activity

Activity

EC50
EC50 ~ 10 µM
Anticancer
10 µM

Target

Lung Cancer
NCl-H510A
Lung

Assay & Model

MTT/Alamamar-Blue/Hexosaminidase activity test
48-72 h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
US20200239547A1