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Peptide record

TPDB42806

Bit1 PA 1 PA 4 Anticancer Cell-penetrating Peptides Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB42806
Bit1 PA 1 PA 4
Anticancer Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP StackTHP StackTHPred TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Anticancer, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
RPARPAR
Physicochemical Analysis
C34H62N16O8
NDCEQGHILKMFSTWYV
R
822.97
12.70
3
0
2
+3
2.99
-1.871
28.57
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C34H62N16O8
822.97
12.70
+3
2.99
-1.871
Free
L
Amphipathic
Linear
RXXR CendR (R/KXXR/K)
Free
N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 8 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PPC-1 and M21

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Fluorophore (Rhodamine)
Vesicles
Clathrin- independent Carriers (CLIC) pathway
In vitro
CCCCSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

PPC-1 and M21

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
DSP-PEG2000 and Fluorophore (Rhodamine)
Vesicles
Higher association compared to peptide 1
Clathrin- independent Carriers (CLIC) pathway
In vitro
CCCCSCC
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Parenchyma cell
Homing
Human prostate carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
2009
Teesalu T et al. Proc Natl Acad Sci U S A. 2009 Sep 22 106(38):16157-62.
US 2009/0246133 A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
PPC-1 human prostate carcinoma xenograft tumors
Phage display library
T7 phage/ cyclic CX7C. library linear X7 peptide library
Quantum dots
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
NRP-1 b1b2

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor vasculature, Tumor cell
Homing
Reticulum cell sarcoma
neuropilin-1 (NRP1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Erythrocyte-binding therapeutics
2024
US 11884721 B2
US 11884721 B2

Other

8-12 wk old female C57BL/6 mice, 8-12 week old female B6.SJL-PtprcaPepcb/Boy (CD45.1) mice
Phage Display library
CX7C, T7 phage library
erythrocyte-binding moiety
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Tumor lymphatic, Tumor cell, Tumor macrophage
Homing
Breast cancer, Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
2019
US 10179801 B2
US 10179801 B2

Other

4T1, MDA-MB-435 Breast cancer cell line, DU145, PPC1
BALB/C athymic nude mice
Phage Display library
T7 phage display library
iron oxide nanoworms
Evidence 8 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Targeting
Breast cancers
neuropilin-1 (NRP-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Application of a proapoptotic peptide to intratumorally spreading cancer therapy
2012
Renwei Chen et al. Cancer Res. 2013 Feb 15 73(4):1352-61

Other

human embryonic kidney (HEK) 293T, prostate cancer PPC1, mouse breast cancer 4T1, Human tumor cell line M21, Human breast cancer cell line MCF-10CA1a, HTB-129 (MDA-MB-435S) line
Athymic nude mice, normal Balb/C mice
Synthetic
CDD (cell death domain)
Additional Detail Fields 5 fields
Quantum dots Nanoworms(NWs), polyethylene glycol erythrocyte-binding moiety nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide] iron oxide nanoworms CDD (cell death domain)
CCCCSCC
PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line 4T1, MDA-MB-435 Breast cancer cell line, DU145, PPC1 human embryonic kidney (HEK) 293T, prostate cancer PPC1, mouse breast cancer 4T1, Human tumor cell line M21, Human breast cancer cell line MCF-10CA1a, HTB-129 (MDA-MB-435S) line
PPC-1 human prostate carcinoma xenograft tumors Athymic nude mice, ApoE null mice 8-12 wk old female C57BL/6 mice, 8-12 week old female B6.SJL-PtprcaPepcb/Boy (CD45.1) mice BALB/c athymic nude mice Athymic nude mice, normal Balb/C mice
T7 phage/ cyclic CX7C. library linear X7 peptide library T7 phage / cyclic Cx7C and linear X7 peptide library CX7C, T7 phage library T7 phage display library