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Peptide record

TPDB42776

RGDGWK RGDGWK-lipopeptide Anticancer Tumor-homing Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB42776
RGDGWK RGDGWK-lipopeptide
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 6-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
RGDGWK
Physicochemical Analysis
C31H47N11O9
ANCEQHILMFPSTYV
G
717.78
10.09
2
1
1
+1
1.20
-2.267
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
766.25
0
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
6
C31H47N11O9
717.78
10.09
+1
1.20
-2.267
RGD
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Melanoma
Integrins Alpha -5 beta- 1

Source & Reference

TumorHoPe2.0
TumorHoPe2
The use of RGDGWK-lipopeptide to selectively deliver genes to mouse tumor vasculature and its complexation with p53 to inhibit tumor growth
2009
Samanta S et al. Biomaterials. 2010 Mar 31(7):1787-97.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Mice bearing the aggressive B16F10 tumor
Phage display library
Anticancer-p-53 gene
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Additional Detail Fields 3 fields
Anticancer-p-53 gene necrosis-inducing peptide, Fluorescein (FAM)
Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
Mice bearing the aggressive B16F10 tumor 6-week-old BalB/C mice