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Peptide record

TPDB42775

Anticancer Tumor-homing Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB42775
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 4-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
C-terminal: Protected with benzyl esters. N-terminal: Protected with (Boc)2O
Sequence
RGDF
Physicochemical Analysis
C21H31N7O7
ANCEQHILKMPSTWYV
RDGF
493.52
6.78
1
1
1
-0
0.92
-1.400
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C21H31N7O7
493.52
6.78
-0
0.92
-1.400
Protected with benzyl esters.
Protected with (Boc)2O
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Homing
Sarcoma
Alpha-5 beta- 3 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
A novel tetrapeptide, RGDF, mediated tumor specific liposomal doxorubicin (DOX) preparations
2011
Du H et al. Mol Pharm. 2011 Aug 1 8(4):1224-32.
US005744515A

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
ICR mice inoculated with sarcoma S180
Synthetic
RGDF-lauryl alcohol conjugate (L-RGDFC12-DOX)
Additional Detail Fields 2 fields
RGDF-lauryl alcohol conjugate (L-RGDFC12-DOX)
ICR mice inoculated with sarcoma S180