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Peptide record

TPDB42771

N-Ter Anticancer Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB42771
N-Ter
Anticancer Cell-penetrating Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 dbACP CPPsite3.0
standard
No
A 12-aa standard natural multi-activity (Anticancer and Cell-penetrating Peptides) peptide sequence curated from CancerPPD 2.0, dbACP, and CPPsite3.0, with an available 3D structural model.
Sequence
RDVFTKGYGFGL
Physicochemical Analysis
C64H94N16O17
ANCEQHIMPSW
G
1359.55
9.74
2
1
5
+1
-0.49
-0.125
56.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
109.60
2
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
3
G
0
H
0
I
1
L
1
K
0
M
2
F
0
P
0
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 1 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
12
C64H94N16O17
1359.55
9.74
+1
-0.49
-0.125
Free
L
Cationic
Linear
Linear
Free
Anticancer
Analogue of N-terminal fragment of the VDAC1 protein
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50(A-375)> 50.0 µM
Anticancer

Target

Skin Cancer
A-375
Skin

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Human Melanoma A375 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Protein derived
Mitochondria
Cannot easily penetrate into the cancer cells
In vitro