TPDB

3D PDB MODEL

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TPDB ID TPDB42752

Peptide_Name

Bombesin

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

QRLGNQWAVGHLM

FASTA

>TPDB42752|Anticancer;Tumor-homing Peptides|length=13
QRLGNQWAVGHLM

Formula C66H104N22O17S1

Absent Amino Acids DCEIKFPSTY

Common Amino Acids QGL

Mass 1509.75

PI 11.05

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +1

Boman Index 0.07

Hydrophobicity -0.338

Aliphatic Index 90.00

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 364.30

Polar Residues 3

number

1

A

1

R

1

N

0

D

0

C

0

E

2

Q

2

G

1

H

0

I

2

L

0

K

1

M

0

F

0

P

0

S

0

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 1 I: 0 L: 2 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1

Length

13

Formula

C66H104N22O17S1

Mass

1509.75

PI

11.05

Net Charge

+1

Boman Index

0.07

Hydrophobicity

-0.338

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Target Tumor Lung, gastric cancer, Neuroblastoma

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Enhancement of cytotoxicity of antimicrobial peptide magainin II in tumor cells by bombesin-targeted delivery

Year 2011

Reference

Liu S et al. Acta Pharmacol Sin. 2011 Jan 32(1):79-88.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo MCF-7, DU145, A375 HeLa, A875, M14, A549, ZR-75-30, Raji, NB4, K562 cell lines

InVivo Model Eight-week-old female nude mice with MCF-7 xenograft

Source Type Natural

Conjugate Payload MG2 peptide

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Receptors Biomarker Gastrin releasing peptide receptor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria

Year 2022

Reference

US 11219671 B1

Patent US 11219671 B1

Other

InVivo Model Salmonella typhimurium

Source Type Phage display library

Phage Display Library Ph.D-7 Phage Display

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Prostate cancer

Receptors Biomarker released peptide (GRP) receptor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

The synthesis of 64Cu-chelated porphyrin photosensitizers and their tumor-targeting peptide conjugates for the evaluation of target cell uptake and PET image-based pharmacokinetics of targeted photodynamic therapy agents

Year 2013

Reference

Hidefumi Mukai et al. Ann Nucl Med. 2013 Aug. 27(7) 625-39

Other

InVitro ExVivo prostate cancer cell line, PC-3

InVivo Model Female BALB/c nu/numice (7weeksold)

Source Type Synthetic

Conjugate Payload Protoporphyrin IX

Evidence 4 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Lung, Breast, Colon, Prostate cancer

Receptors Biomarker gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) bombesin receptor subtype 3 (BRS-3)

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Enhancing the circulating half-life and the antitumor effects of a tumor-selective cytotoxic peptide by exploiting endogenous serum albumin as a drug carrier

Year 2016

Reference

Tao Su et al. Int J Pharm. 2016 Feb 29 499(1-2):195-204.

Other

InVitro ExVivo COLO 205, K562, and SMMC-7721 tumor cells

InVivo Model Female athymic 4–5-week-old BALB/c mice

Source Type Synthetic

Conjugate Payload mitochondria-disrupting peptide

Evidence 5 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Bombesin analogue-mediated delivery preferentially enhances the cytotoxicity of a mitochondria-disrupting peptide in tumor cells

Year 2013

Reference

Hao Yang et al. PLoS One. 2013 8(2):e57358.

Other

InVitro ExVivo DU145 tumor cells

InVivo Model BALB/c nude mice, BALB/c nu/nu mice

Source Type Synthetic

Conjugate_Payload

MG2 peptide Protoporphyrin IX mitochondria-disrupting peptide

InVitro_ExVivo

MCF-7, DU145, A375 HeLa, A875, M14, A549, ZR-75-30, Raji, NB4, K562 cell lines prostate cancer cell line, PC-3 COLO 205, K562, and SMMC-7721 tumor cells DU145 tumor cells

InVivo_Model

Eight-week-old female nude mice with MCF-7 xenograft Salmonella typhimurium Female BALB/c nu/numice (7weeksold) Female athymic 4–5-week-old BALB/c mice BALB/c nude mice, BALB/c nu/nu mice

Phage_Display_Library

Ph.D-7 Phage Display