TPDB

3D PDB MODEL

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TPDB ID TPDB42737

Activity

Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 48-aa standard natural multi-activity (Anticancer, Antifungal, and Antiparasitic) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.

Sequence

QKLCERSSGTWSGVCGNNNACKNQCINLEGARHGSCNYIFPYHRCICY

FASTA

>TPDB42737|Anticancer;Antifungal;Antiparasitic|length=48
QKLCERSSGTWSGVCGNNNACKNQCINLEGARHGSCNYIFPYHRCICY

Formula C226H346N72O69S7

Absent Amino Acids DM

Common Amino Acids C

Mass 5400.09

PI 8.19

Basic Residues 7

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +3

Boman Index 5.41

Hydrophobicity -0.537

Aliphatic Index 50.83

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 10345

Absorbance 280nm 191.57

Polar Residues 23

number

2

A

3

R

6

N

0

D

7

C

2

E

2

Q

5

G

2

H

3

I

2

L

2

K

0

M

1

F

1

P

4

S

1

T

1

W

3

Y

1

V

Amino Acid Distribution

A: 2 R: 3 N: 6 D: 0 C: 7 E: 2 Q: 2 G: 5 H: 2 I: 3 L: 2 K: 2 M: 0 F: 1 P: 1 S: 4 T: 1 W: 1 Y: 3 V: 1

Length

48

Formula

C226H346N72O69S7

Mass

5400.09

PI

8.19

Net Charge

+3

Boman Index

5.41

Hydrophobicity

-0.537

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 5 µg/mL

Target

Target Organism A. brassicola

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against fungi A. brassicola (IC50 5 ug/ml), B. cinerea (IC50 9 ug/ml), and F. culmorum (IC50 11 ug/ml). Updated 7/2021 Seq updated

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 9 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against fungi A. brassicola (IC50 5 ug/ml), B. cinerea (IC50 9 ug/ml), and F. culmorum (IC50 11 ug/ml). Updated 7/2021 Seq updated 2/2023

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 11 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against fungi A. brassicola (IC50 5 ug/ml), B. cinerea (IC50 9 ug/ml), and F. culmorum (IC50 11 ug/ml). Updated 7/2021 Seq updated 2/2023

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 5 µg/mL

Target

Target Organism A. brassicola

Source & Reference

Database Source NA

Other

Evidence Text

active against fungi A. brassicola (IC50 5 ug/ml), B. cinerea (IC50 9 ug/ml), and F. culmorum (IC50 11 ug/ml). Updated 7/2021 Seq updated

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 9 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source NA

Other

Evidence Text

active against fungi A. brassicola (IC50 5 ug/ml), B. cinerea (IC50 9 ug/ml), and F. culmorum (IC50 11 ug/ml). Updated 7/2021 Seq updated 2/2023

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 11 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source NA

Other

Evidence Text

active against fungi A. brassicola (IC50 5 ug/ml), B. cinerea (IC50 9 ug/ml), and F. culmorum (IC50 11 ug/ml). Updated 7/2021 Seq updated 2/2023