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Peptide record

TPDB42728

Clone PC5-8 Anticancer Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB42728
Clone PC5-8
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
QHAPSNSKSVLT
Physicochemical Analysis
C53H89N17O19
RDCEGIMFWY
S
1268.39
10.10
2
0
3
+1
3.27
-0.750
65.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
0
0.00
6
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
1
Q
0
G
1
H
0
I
1
L
1
K
0
M
0
F
1
P
3
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 3 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C53H89N17O19
1268.39
10.10
+1
3.27
-0.750
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing (Phage display clone)
Lung cancer
Integrins, Alpha-5 beta-3 and Alpha-5 beta-5

Source & Reference

TumorHoPe2.0
TumorHoPe2
Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery
2007
Lee TY et al. Cancer Res. 2007 Nov 15 67(22):10958-65.
US 2008/0193510A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
Phage display library
M13 phage/random peptide library
Additional Detail Fields 3 fields
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
M13 phage/random peptide library