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Peptide record

TPDB42702

D-SP5 Anticancer Cell-penetrating Peptides Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB42702
D-SP5
Anticancer Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CancerPPD 2.0 CPPsite3.0 TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Anticancer, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from CancerPPD 2.0, CPPsite3.0, and TumorHoPe2.0, with an available 3D structural model.
Sequence
PRPSPKMGVSVS
Physicochemical Analysis
C53H92N16O16S1
ANDCEQHILFTWY
PS
1241.47
11.49
2
0
3
+2
3.46
-0.475
48.33
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
1
M
0
F
3
P
3
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 1 F: 0 P: 3 S: 3 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
12
C53H92N16O16S1
1241.47
11.49
+2
3.46
-0.475
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Targeting

Source & Reference

TumorHoPe2.0
TumorHoPe2
2013
Ying Li et al. Bioconjug Chem. 2013 Jan 16 24(1):133-43.

Other

KB, U87, SGC, HUVEC tumor cell line
PEG-DSPE micelles
Additional Detail Fields 3 fields
necrosis-inducing peptide, Fluorescein (FAM) PEG-DSPE micelles
Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line KB, U87, SGC, HUVEC tumor cell line
6-week-old BalB/C mice