TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB42700

Peptide_Name

Clone G3-C60

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

PRNICSRRDPTCWTTY

FASTA

>TPDB42700|Anticancer;Tumor-homing Peptides|length=16
PRNICSRRDPTCWTTY

Formula C83H129N27O25S2

Absent Amino Acids AEQGHLKMFV

Common Amino Acids RT

Mass 1969.22

PI 9.09

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 3

Net Charge +2

Boman Index 1.95

Hydrophobicity -1.206

Aliphatic Index 24.38

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 7115

Absorbance 280nm 361.31

Polar Residues 8

number

0

A

3

R

1

N

1

D

2

C

0

E

0

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

2

P

1

S

3

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 3 N: 1 D: 1 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 1 T: 3 W: 1 Y: 1 V: 0

Length

16

Formula

C83H129N27O25S2

Mass

1969.22

PI

9.09

Net Charge

+2

Boman Index

1.95

Hydrophobicity

-1.206

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell and tumor cell

Homing or Targeting Targeting

Target Tumor Tumor metastasis

Receptors Biomarker Galectin-3

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion

Year 2005

Reference

Zou J et al. Carcinogenesis. 2005 Feb 26(2):309-18.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo

Saos2 (derived from a human osteosarcoma),Human breast cancer cell lines BT549, express detectable levels of galectin-3 ,BT549trans,Human breast carcinoma cell line MDA-MB-435,Human prostate carcinoma cell line PC-3M

Source Type Phage display library

Phage Display Library f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library

InVitro_ExVivo

Saos2 (derived from a human osteosarcoma),Human breast cancer cell lines BT549, express detectable levels of galectin-3 ,BT549trans,Human breast carcinoma cell line MDA-MB-435,Human prostate carcinoma cell line PC-3M

Phage_Display_Library

f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library