TPDB

3D PDB MODEL

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TPDB ID TPDB42688

Peptide_Name

G3-A9

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Modification

N-terminal: Biotinylation

Sequence

PQNSKIPGPTFLDPH

FASTA

>TPDB42688|Anticancer;Tumor-homing Peptides|length=15
PQNSKIPGPTFLDPH

Formula C75H114N20O22

Absent Amino Acids ARCEMWYV

Common Amino Acids P

Mass 1647.85

PI 7.81

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 3

Net Charge +0

Boman Index 4.26

Hydrophobicity -0.987

Aliphatic Index 52.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

0

A

0

R

1

N

1

D

0

C

0

E

1

Q

1

G

1

H

1

I

1

L

1

K

0

M

1

F

4

P

1

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 1 K: 1 M: 0 F: 1 P: 4 S: 1 T: 1 W: 0 Y: 0 V: 0

Length

15

Formula

C75H114N20O22

Mass

1647.85

PI

7.81

Net Charge

+0

Boman Index

4.26

Hydrophobicity

-0.987

Motif

P-(C)-G-P-XXX-D(C)-P

N_terminal_Modification

Biotinylation

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell and tumor cell

Homing or Targeting Targeting & further studied

Target Tumor Tumor metastasis

Receptors Biomarker Galectin-3

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion

Year 2005

Reference

Zou J et al. Carcinogenesis. 2005 Feb 26(2):309-18.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo

Human breast cancer cell lines BT549, express detectable levels of galectin-3, BT549 trans, Human breast carcinoma cell line MDA-MB-435, Human prostate carcinoma cell line PC-3M, MDA-MB-435 human breast carcinoma cells on HBME-1 monolayers

Source Type Phage display library

Phage Display Library f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library

InVitro_ExVivo

Human breast cancer cell lines BT549, express detectable levels of galectin-3, BT549 trans, Human breast carcinoma cell line MDA-MB-435, Human prostate carcinoma cell line PC-3M, MDA-MB-435 human breast carcinoma cells on HBME-1 monolayers

Phage_Display_Library

f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library