TPDB

3D PDB MODEL

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TPDB ID TPDB42664

Peptide_Name

Clone 6(9)

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

PIHYIF

FASTA

>TPDB42664|Anticancer;Tumor-homing Peptides|length=6
PIHYIF

Formula C41H56N8O8

Absent Amino Acids ARNDCEQGLKMSTWV

Common Amino Acids I

Mass 788.94

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +0

Boman Index -1.28

Hydrophobicity 0.950

Aliphatic Index 130.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 1490

Absorbance 280nm 188.86

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

2

I

0

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

6

Formula

C41H56N8O8

Mass

788.94

PI

7.77

Net Charge

+0

Boman Index

-1.28

Hydrophobicity

0.950

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Plasma cell

Homing or Targeting Targeting

Target Tumor Multiple myeloma

Receptors Biomarker M-protein

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Identification of patient-specific peptides for detection of M-proteins and myeloma cells

Year 1999

Reference

Szecsi PB et al. Br J Haematol. 1999 Nov 107(2):357-64.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo ELISA ASSAY on patients serum

Source Type Phage display library

Phage Display Library M13 phage/ Random 6-mer peptide library & M13 phage/ 15-mer peptide library.

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor multiple myeloma

Receptors Biomarker M-protein

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria

Year 2022

Reference

US 11219671 B1

Patent US 11219671 B1

Other

InVivo Model Salmonella typhimurium

Source Type Phage display library

Phage Display Library Ph.D-7 Phage Display

InVitro_ExVivo

ELISA ASSAY on patients serum

InVivo_Model

Salmonella typhimurium

Phage_Display_Library

M13 phage/ Random 6-mer peptide library & M13 phage/ 15-mer peptide library. Ph.D-7 Phage Display