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Peptide record

TPDB42628

IturinA Anticancer standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB42628
IturinA
Anticancer
Cancer-related peptides
CancerPPD 2.0
standard
No
A 7-aa standard natural anticancer peptide sequence curated from CancerPPD 2.0, with an available 3D structural model.
C-terminal: C16 Fatty acid moiety C-terminal: Cyclized N-terminal: Cyclized
Sequence
NYNQPNS
Physicochemical Analysis
C34H49N11O14
ARDCEGHILKMFTWV
N
835.83
5.94
0
0
1
-0
1.48
-2.529
0.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
1490
178.27
6
Residue Composition
number
0
A
0
R
3
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 3 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
7
C34H49N11O14
835.83
5.94
-0
1.48
-2.529
Cyclized C16 Fatty acid moiety
L
Cyclic
Cyclized
Lipopeptide
Bacillus megaterium
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
IC50 = 7.98 ± 0.19 µM
Anticancer
7.98

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 12.16 ± 0.24 µM
Anticancer
12.16

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 3 Activity

Activity

IC50
IC50 = 26.29 ± 0.78 µM
Anticancer
26.29

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 4 Activity

Activity

IC50
IC50 = 13.30 ± 0.97 µM
Anticancer
13.30

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015