TPDB

3D PDB MODEL

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TPDB ID TPDB42623

Peptide_Name

TMTP1

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

NVVRQ

FASTA

>TPDB42623|Anticancer;Tumor-homing Peptides|length=5
NVVRQ

Formula C25H46N10O8

Absent Amino Acids ADCEGHILKMFPSTWY

Common Amino Acids V

Mass 614.70

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 1.95

Hydrophobicity -0.620

Aliphatic Index 116.00

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

1

R

1

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

5

Formula

C25H46N10O8

Mass

614.70

PI

11.05

Net Charge

+1

Boman Index

1.95

Hydrophobicity

-0.620

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Prostate cancer, Gastric cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

[Antitumor and antimetastatic effect of antimicrobial peptide conjugated with tumor homing peptide TMTP1 on the transplanted prostate cancer and gastric cancer in nude mice]

Year 2013

Reference

Xiang-yi Ma et al. Zhonghua Zhong Liu Za Zhi. 2013 Oct 35(10):737-41

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVivo Model Nude mice

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Ovarian cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title M11: A Tropism-Modified Oncolytic Adenovirus Arming with a Tumor-Homing Peptide for Advanced Ovarian Cancer Therapies

Year 2022

Reference

Fei Li et al. Hum Gene Ther. 2022 Mar 33(5-6):262-274.

Other

Conjugate Payload OAd vector, M0, cisplatin

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Target Tumor Hepatocellular carcinoma

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Year 2022

Reference

Lanlin Yao et al. Mol Pharm. 2022 Sep 5 19(9):3178-3186.

Other

Conjugate Payload radiotherapeutic probe, [177Lu]Lu-DOTA-EB

Evidence 4 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Ovarian cancer and Gastric cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Evaluation of (99m)Tc-HYNIC-TMTP1 as a tumor-homing imaging agent targeting metastasis with SPECT

Year 2015

Reference

Li F et al. Nucl Med Biol. 2015 Mar 42(3):256-62.

Other

InVitro ExVivo MNK-45, Human Serous Ovarian Cancer cells (SKOV3.ip), Human Serous Ovarian cells (SKOV3)

InVivo Model Tumor bearing nude mice injected with SKOV3.ip cells, SKOV3 cells and MNK-45 cells

Source Type Synthetic

Conjugate Payload Rhodamine

Evidence 5 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Pacifastin-derived Peptides Target Tumors for Use in In Vivo Imaging

Year 2018

Reference

Sottero TL et al. Anticancer Res. 2018 Jan 38(1):51-60.

Other

InVitro ExVivo RH28 and Ramos, A375, 204, A673

InVivo Model Athymic nu/nu mice(Harlan) bearing Ramos flank tumors

Source Type Synthetic

Conjugate Payload MMAE

Evidence 6 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor Ovarain cancer

Receptors Biomarker Aminopeptidase P (XPNPEP2)

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Codelivery of adavosertib and olaparib by tumor-targeting nanoparticles for augmented efficacy and reduced toxicity

Year 2023

Reference

Wang W et al. Acta Biomater. 2023 Feb:157:428-441.

Other

InVitro ExVivo Human OC cell line (OVCAR8, SKOV3), Human Umbilical Vein Endothelial cells (HUVEC), Human Fetal Lung Fibroblasts (MRC5)

InVivo Model 5 weeks old Female BALB/c nude mice bearing OVCAR8 tumor

Source Type Phage Display Library

Phage Display Library FliTrx bacterial peptide display system

Conjugate Payload Alexa Flour 488 (A488)

Conjugate_Payload

OAd vector, M0, cisplatin radiotherapeutic probe, [177Lu]Lu-DOTA-EB Rhodamine MMAE Alexa Flour 488 (A488)

InVitro_ExVivo

MNK-45, Human Serous Ovarian Cancer cells (SKOV3.ip), Human Serous Ovarian cells (SKOV3) RH28 and Ramos, A375, 204, A673 Human OC cell line (OVCAR8, SKOV3), Human Umbilical Vein Endothelial cells (HUVEC), Human Fetal Lung Fibroblasts (MRC5)

InVivo_Model

Nude mice Tumor bearing nude mice injected with SKOV3.ip cells, SKOV3 cells and MNK-45 cells Athymic nu/nu mice(Harlan) bearing Ramos flank tumors 5 weeks old Female BALB/c nude mice bearing OVCAR8 tumor

Phage_Display_Library

FliTrx bacterial peptide display system