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Peptide record

TPDB42621

Clone PC5-5 Anticancer Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB42621
Clone PC5-5
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
NTLPPFSPPSPP
Physicochemical Analysis
C59H87N13O17
ARDCEQGHIKMWYV
P
1250.42
6.02
0
0
2
-0
1.83
-0.733
32.50
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
6
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 6 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C59H87N13O17
1250.42
6.02
-0
1.83
-0.733
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing (Phage display clone)
Lung cancer
Integrins, Alpha-5 beta-3 and Alpha-5 beta-5

Source & Reference

TumorHoPe2.0
TumorHoPe2
Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery
2007
Lee TY et al. Cancer Res. 2007 Nov 15 67(22):10958-65.
US 2008/0193510A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
Phage display library
M13 phage/random peptide library
Additional Detail Fields 3 fields
CL1-5 (lung cancer), H460 (lung cancer) ,PC-3 (prostate cancer),VEGF-stimulated HUVECs and human lung cancer vessels
SCID mice with lung cancer xenograft
M13 phage/random peptide library