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Peptide record

TPDB42600

ACE inhibitor ACE inhibitors Anticancer Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB42600
ACE inhibitor
ACE inhibitors Anticancer Antihypertensive
Cardiometabolic peptides Cancer-related peptides
FermFooDB Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors, Anticancer, and Antihypertensive) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
NLHLPLPLL
Physicochemical Analysis
C50H84N12O11
ARDCEQGIKMFSTWYV
L
1029.29
7.85
1
0
5
+0
-0.52
1.011
216.67
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
5
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 5 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C50H84N12O11
1029.29
7.85
+0
-0.52
1.011
1029.2724
1028.6363
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
15.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Robert M. C., Razaname A., Mutter M., Juillerat M. A.
Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765. J. Agric. Food. Chem., 52, 6923-6931, 2004
2004
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C50H84N12O11/c1-26(2)17-33(55-42(64)32(51)23-41(52)63)43(65)56-35(22-31-24-53-25-54-31)45(67)58-36(19-28(5)6)48(70)62-16-12-14-40(62)47(69)59-37(20-29(7)8)49(71)61-15-11-13-39(61)46(68)57-34(18-27(3)4)44(66)60-38(50(72)73)21-30(9)10/h24-30,32-40H,11-23,51H2,1-10H3,(H2,52,63)(H,53,54)(H,55,64)(H,56,65)(H,57,68)(H,58,67)(H,59,69)(H,60,66)(H,72,73)/t32-,33-,34-,35-,36-,37-,38-,39-,40-/m0/s1 InChIKey=PLSNHYPQMRIMOR-LCQMPJFHSA-N Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8315), the DFBP database
Evidence 2 Activity

Activity

IC50
Antihypertensive
15.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Robert M. C., Razaname A., Mutter M., Juillerat M. A.
Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765. J. Agric. Food. Chem., 52, 6923-6931, 2004
2004
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C50H84N12O11/c1-26(2)17-33(55-42(64)32(51)23-41(52)63)43(65)56-35(22-31-24-53-25-54-31)45(67)58-36(19-28(5)6)48(70)62-16-12-14-40(62)47(69)59-37(20-29(7)8)49(71)61-15-11-13-39(61)46(68)57-34(18-27(3)4)44(66)60-38(50(72)73)21-30(9)10/h24-30,32-40H,11-23,51H2,1-10H3,(H2,52,63)(H,53,54)(H,55,64)(H,56,65)(H,57,68)(H,58,67)(H,59,69)(H,60,66)(H,72,73)/t32-,33-,34-,35-,36-,37-,38-,39-,40-/m0/s1 InChIKey=PLSNHYPQMRIMOR-LCQMPJFHSA-N Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8315), the DFBP database
Additional Detail Fields 1 fields
9