TPDB

3D PDB MODEL

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TPDB ID TPDB42598

Peptide_Name

Clone G3-C44

Activity

Anticancer Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

Peptipedia StackTHP StackTHPred TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.

Sequence

NISRCTHPFMACGKQS

FASTA

>TPDB42598|Anticancer;Tumor-homing Peptides|length=16
NISRCTHPFMACGKQS

Formula C73H118N24O22S3

Absent Amino Acids DELWYV

Common Amino Acids CS

Mass 1780.07

PI 9.15

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +2

Boman Index 2.30

Hydrophobicity -0.431

Aliphatic Index 30.63

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 7.02

Polar Residues 7

number

1

A

1

R

1

N

0

D

2

C

0

E

1

Q

1

G

1

H

1

I

0

L

1

K

1

M

1

F

1

P

2

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 0 K: 1 M: 1 F: 1 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 0

Length

16

Formula

C73H118N24O22S3

Mass

1780.07

PI

9.15

Net Charge

+2

Boman Index

2.30

Hydrophobicity

-0.431

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell and tumor cell

Homing or Targeting Targeting

Target Tumor Tumor metastasis

Receptors Biomarker Galectin-3

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion

Year 2005

Reference

Zou J et al. Carcinogenesis. 2005 Feb 26(2):309-18.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo

Saos2 (derived from a human osteosarcoma),Human breast cancer cell lines BT549, express detectable levels of galectin-3 ,BT549trans,Human breast carcinoma cell line MDA-MB-435,Human prostate carcinoma cell line PC-3M

Source Type Phage display library

Phage Display Library f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library

InVitro_ExVivo

Saos2 (derived from a human osteosarcoma),Human breast cancer cell lines BT549, express detectable levels of galectin-3 ,BT549trans,Human breast carcinoma cell line MDA-MB-435,Human prostate carcinoma cell line PC-3M

Phage_Display_Library

f88 phage/15mer peptide library and f88 phage/Cys6 mer peptide library