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Peptide record

TPDB42595

Anticancer Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB42595
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
N-terminal: Modification at N-terminal to give cysteine moiety at the end.
Sequence
NGRSL
Physicochemical Analysis
C21H39N9O8
ADCEQHIKMFPTWYV
RNGLS
545.60
11.05
1
0
1
+1
0.81
-1.080
78.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C21H39N9O8
545.60
11.05
+1
0.81
-1.080
NGR
Modification at N-terminal to give cysteine moiety at the end.
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Neuroblastoma
Aminopeptidase N

Source & Reference

TumorHoPe2.0
TumorHoPe2
Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy
2003
Pastorino F et al. Cancer Res. 2003 Nov 1 63(21):7400-9.
US 2009/0092663A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Five human NB cell lines GI-ME-N, GI-LI-N, HTLA-230, IMR-32, and SH-SY5Y, KS1767 cells
Orthotopic neuroblastoma (NB) xenografts in SCID mice
Synthetic
Liposomal doxorubicin (NGR-SL[DXR])
Pharmacokinetic studies indicated that liposomes coupled to NGR peptide had long-circulating profiles in blood
Additional Detail Fields 3 fields
Liposomal doxorubicin (NGR-SL[DXR])
Five human NB cell lines GI-ME-N, GI-LI-N, HTLA-230, IMR-32, and SH-SY5Y, KS1767 cells
Orthotopic neuroblastoma (NB) xenografts in SCID mice