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Peptide record

TPDB42591

Anticancer Tumor-homing Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB42591
Anticancer Tumor-homing Peptides
Cancer-related peptides
Peptipedia StackTHP StackTHPred TumorHoPe2.0
standard
No
A 6-aa standard natural multi-activity (Anticancer and Tumor-homing Peptides) peptide sequence curated from Peptipedia, StackTHP, StackTHPred, and other sources, with an available 3D structural model.
Sequence
NGRAHA
Physicochemical Analysis
C24H40N12O8
DCEQILKMFPSTWYV
A
624.66
11.05
2
0
2
+1
1.86
-1.333
33.33
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C24H40N12O8
624.66
11.05
+1
1.86
-1.333
NGR
Evidence Records 4 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Human Kaposi's Sarcoma
Integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
1999
Arap W et al. Science. 1998 Jan 16 279(5349):377-80.
PATENT NO 5536814

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Mice bearing MDA-MB-435derived tumors, SLK cell derived human Kaposi's sarcoma xenografts
Phage display library
M13 Phage/CX3CX3CX3C peptide library
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor vasculature
Targeting

Source & Reference

TumorHoPe2.0
TumorHoPe2
Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria
2022
US 11219671 B1
US 11219671 B1

Other

Salmonella typhimurium
Phage display library
Ph.D-7 Phage Display
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Additional Detail Fields 4 fields
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
Mice bearing MDA-MB-435derived tumors, SLK cell derived human Kaposi's sarcoma xenografts Salmonella typhimurium BALB/c athymic nude mice
M13 Phage/CX3CX3CX3C peptide library Ph.D-7 Phage Display T7 phage display library