TPDB

3D PDB MODEL

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TPDB ID TPDB42542

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

dbACP

Sequence_Type

standard

Has_Modification No

Description A 3135-aa standard natural anticancer peptide sequence curated from dbACP, with an available 3D structural model.

Sequence

MTPLSYAQRRMWFINRFEGPSSTYNIPLLLRCHGPLDTVALRAAFRDVMVRHEVLRTVFAETDGQPYQRVLDPADIDLPWQDWGRVAPERVPGVVESVSGSWFDLSADVPLRGCVLQSGDEEYLVVLVLHHIAGDGGSLAPLARDVSTAYRARVTGTEPDWPELPVQYSDYALWQQEMLGDEKDPDSIVSVQSAYWGEELAGVSKPLPLPLDRPRPEVATFRGDSVPVGLPAELRAAVERLAQSNGVTTAIVLQTALVVLLHRLGGGKDVTVGSPIAGRTEEALNELVGFFVNTWTLRVQVSADRSFAWVLEQVRKKAIAAYDHQDVPFERLVEILRPERSTAHHPLFQVVLAWQNNTPPHLDLPGLTVTMEPLPTGSAKFDLFFNLAPDDVTGSVVGEIEYATDLFDRSTVEDVAARFVAVVEEVVADPTTSVGTAVAAGTGRSGNSLDAAERHRILVEWNDTARSVPCPGPVHLLFEEQAARRPDAVALRWAAGTMTYGELNRWANRVAWDLKERGVGPETVVGVGVPRGPAMIAAVLGVLKAGGAYLPLETALPAERVAGMLEDAGCALVLSTPDTERWALPDHVAFAELAGARSTGAYHDPEPAAGPDNTAYIIFTSGSTGKPKGVAVTHRPVHNLLKWCYRTFAFGPDDVVLCVTSLGFDLSVFDIFGLLGCGGGVYLADAVQQRDPHLLLDVLLSEPITFWDSVPTTLNQVASLLTEDGGYEGTDDLRLVFLSGDYTPLSLPDEVRRVFTGAEIVSLGGATEATVWSNYFRVREIDPSWRSIPYGRPIDNARYYVLDEDMEPCPVGVEGDLYIGGDCLCVGYVNRPELTAERFVRDPFSTREGDRLYRTGDRAAFFPDGNICFLGRADNQVKLRGFRVEPGEIEHALVRHPAVRQAIVTAREDQPGDLRLVAYVVPDTAALPSAGGTQDQVGEWQEVYDQAYSDDGGHVFGEDFTGWNGSATGEPIPVEEMRAWRDAAVAGVMRWSPERVLELGAGTGLLLAHIAGRVREYWATDLSRAVIDRLRDQVTRAGLADRVRLRHQAADDLTGLPAGGFDTVVLNSVVQYFPDERYLARVLDGAWRLLAPGGRIVLGDIRRAASLRTLQTGVQRARHPDATPAVLRTIVEQAVLLEKELVLDPEWFLRWAQDAGATGADIRVKDGTHHNELTRHRYEVVLHKPGTGPAHAPRRLDDAPALVWEGDLDRLADRLGGRPEAAVRITGIPNARLTDEAAAARALTPDDSAEPGPPPLDPAEIRAWAARHGWDAVPTWSADAPDLLDVVVMLDGPAPRTPLTGTYLPATDGRATASDPAVAAAVTALLPALRGHLRETLPEYMIPAAVVPIAAVPLTDNGKPDRRALPAPDYTAGGGRAPGTPEEESLCALFAAVLGLDRVGVDDNFFTIGGHSLLATRLVSRIRAEHGVEIPIRAVFQSPTVAELAAHLTAADDLRPPLRPQPRPERLPLSYAQQRLWFIHRFEGPSATYNIALALRMRGTLDASALRRAVHDVVERHESLRTVFGEADGQPYQRILPPASVEVPWEEREVTEAELPGLLREAARRPFDLATEIPLRTWLLRTGPREAVFLIGAHHIAADGWSALPLAEDLTTAYETRQAGRTPTWEPLSVQYADYTLWQRDLLGDSENPDSLYRRQLDYWTTRLAGLPETVTPPTDRPRPAVASYAGDLVPLTLDAELTDGVRRMARESGATVSMVLQAALAALLTRLGSGTDVPIGSPIAGRTDEALNRLVGFFVNTWVLRADTSGDPSFAELVGRVREDSLAAYDHQDIPFEHLVEVLNPVRSPAHHPLFQVCLALQNNTRPEFHLTGLTVTEEPFSLGTARFDLFISVTERDEEGAPSRIEGFAEYATELFDEGTVRTLLDRWRHFLRQAVAAPDTPIGSVGVLTEAESAALDAWGGPSRDAGSRTGTVTERFAAAAAATPDATALVAADSAHTWTYAELDRWANRLAHHFRARGVRPADRVALVMERSPLLIAAVLGVLKTGAAYAPVDPSYPPERIDFLLADLAPAVTVDEALAEVDLSGLPDSPPDTTGPGEHAVAYVMYTSGSTGRPKGVEVTHRNVVDLALDGCFRNGAHRRVLVHSPHTFDASTYEMWVPLLGGGTAVVARVGRPDTAELARLVAEREVTALWLTAGLFAVMAEQHAECFGGVREVWAGGDVLSPSAVRTVLDACPGLTVVNGYGPTETTTFASRHRMTSAEQGAGPLPIGSPMDGSRLLVLDDRLRPVPPGVVGELYIGGDGVARGYAGRPGLTATRFVPDPASKAGGRVYRTGDLVRWDGAGRLHYVSRSDDQLKLRGFRVEPGELEAVLREQEGVANAVVAVRSDRLGERRMVAYVVPGDTASTGRDAAEQVDEWREVYDTMYGGTEVATDTVGEDFTGWNSSYTGLPIPLEEMRSWREAVLRRVRSLRPLRVLEIGVGSGLLLGPLAPETEEYWGTDFSAPVIERLRAQTRADRRLADKVTLRCGPAHDAEGLPAGYFDTVILNSVVQYFPDADYLGRVLDLAMDRLAPGGRVVLGDVRNHRTLRTFAAAVHRCRQPADGPAAVQAAVERAVLAEKELVVDPGFFTRYAETHPDTVAADIRLKQGTHHNELTRHRYEVVLHKAPAKPLDLGDLPEAVWASEVRELDDLDAALARHGGRLRLTRVPNARLAGEAAEWGAPAELGGTLDPAELEAWGAGRGLAVYCTWSPQAGDFFEAAVVPDVDAVCCDGLYRSTGAPAARLANVPAVSRRASRLPSVLRGRLVGRLPEFMMPAEIVVLDRLPLTENGKVDRAALPEPDPVDGEHRAPRTPREEQLAELFAEVLGLDRIGIDDDFFACGGHSLRLTRLAWQIREKLGVDVPIRTVFQYPTVAELAAQLTTDTDAQFEDPFAVLLPIRTEGQQPPLWWLHPGGGLSWPYLGFARHLDPGRPLYGIQARGFDGTTAPAASIEEMVEDYLEQVLRVQPSGPYHLLGWSFGGTLAHAMAAELQRRGHEVALLALLDAAPSSHFADLEALDESMVRRYLANYMGHLAGMEEYPSLVTTASSIFIGQMEQMRRFTSPRYRGDVVFFNALLDPETHDKRVMDEDLDVLWQDHVDGRVQRIDIPCAHNEMYWPRNAAEISRTINRMLRASQ

FASTA

>TPDB42542|Anticancer|length=3135
MTPLSYAQRRMWFINRFEGPSSTYNIPLLLRCHGPLDTVALRAAFRDVMVRHEVLRTVFAETDGQPYQRVLDPADIDLPWQDWGRVAPERVPGVVESVSGSWFDLSADVPLRGCVLQSGDEEYLVVLVLHHIAGDGGSLAPLARDVSTAYRARVTGTEPDWPELPVQYSDYALWQQEMLGDEKDPDSIVSVQSAYWGEELAGVSKPLPLPLDRPRPEVATFRGDSVPVGLPAELRAAVERLAQSNGVTTAIVLQTALVVLLHRLGGGKDVTVGSPIAGRTEEALNELVGFFVNTWTLRVQVSADRSFAWVLEQVRKKAIAAYDHQDVPFERLVEILRPERSTAHHPLFQVVLAWQNNTPPHLDLPGLTVTMEPLPTGSAKFDLFFNLAPDDVTGSVVGEIEYATDLFDRSTVEDVAARFVAVVEEVVADPTTSVGTAVAAGTGRSGNSLDAAERHRILVEWNDTARSVPCPGPVHLLFEEQAARRPDAVALRWAAGTMTYGELNRWANRVAWDLKERGVGPETVVGVGVPRGPAMIAAVLGVLKAGGAYLPLETALPAERVAGMLEDAGCALVLSTPDTERWALPDHVAFAELAGARSTGAYHDPEPAAGPDNTAYIIFTSGSTGKPKGVAVTHRPVHNLLKWCYRTFAFGPDDVVLCVTSLGFDLSVFDIFGLLGCGGGVYLADAVQQRDPHLLLDVLLSEPITFWDSVPTTLNQVASLLTEDGGYEGTDDLRLVFLSGDYTPLSLPDEVRRVFTGAEIVSLGGATEATVWSNYFRVREIDPSWRSIPYGRPIDNARYYVLDEDMEPCPVGVEGDLYIGGDCLCVGYVNRPELTAERFVRDPFSTREGDRLYRTGDRAAFFPDGNICFLGRADNQVKLRGFRVEPGEIEHALVRHPAVRQAIVTAREDQPGDLRLVAYVVPDTAALPSAGGTQDQVGEWQEVYDQAYSDDGGHVFGEDFTGWNGSATGEPIPVEEMRAWRDAAVAGVMRWSPERVLELGAGTGLLLAHIAGRVREYWATDLSRAVIDRLRDQVTRAGLADRVRLRHQAADDLTGLPAGGFDTVVLNSVVQYFPDERYLARVLDGAWRLLAPGGRIVLGDIRRAASLRTLQTGVQRARHPDATPAVLRTIVEQAVLLEKELVLDPEWFLRWAQDAGATGADIRVKDGTHHNELTRHRYEVVLHKPGTGPAHAPRRLDDAPALVWEGDLDRLADRLGGRPEAAVRITGIPNARLTDEAAAARALTPDDSAEPGPPPLDPAEIRAWAARHGWDAVPTWSADAPDLLDVVVMLDGPAPRTPLTGTYLPATDGRATASDPAVAAAVTALLPALRGHLRETLPEYMIPAAVVPIAAVPLTDNGKPDRRALPAPDYTAGGGRAPGTPEEESLCALFAAVLGLDRVGVDDNFFTIGGHSLLATRLVSRIRAEHGVEIPIRAVFQSPTVAELAAHLTAADDLRPPLRPQPRPERLPLSYAQQRLWFIHRFEGPSATYNIALALRMRGTLDASALRRAVHDVVERHESLRTVFGEADGQPYQRILPPASVEVPWEEREVTEAELPGLLREAARRPFDLATEIPLRTWLLRTGPREAVFLIGAHHIAADGWSALPLAEDLTTAYETRQAGRTPTWEPLSVQYADYTLWQRDLLGDSENPDSLYRRQLDYWTTRLAGLPETVTPPTDRPRPAVASYAGDLVPLTLDAELTDGVRRMARESGATVSMVLQAALAALLTRLGSGTDVPIGSPIAGRTDEALNRLVGFFVNTWVLRADTSGDPSFAELVGRVREDSLAAYDHQDIPFEHLVEVLNPVRSPAHHPLFQVCLALQNNTRPEFHLTGLTVTEEPFSLGTARFDLFISVTERDEEGAPSRIEGFAEYATELFDEGTVRTLLDRWRHFLRQAVAAPDTPIGSVGVLTEAESAALDAWGGPSRDAGSRTGTVTERFAAAAAATPDATALVAADSAHTWTYAELDRWANRLAHHFRARGVRPADRVALVMERSPLLIAAVLGVLKTGAAYAPVDPSYPPERIDFLLADLAPAVTVDEALAEVDLSGLPDSPPDTTGPGEHAVAYVMYTSGSTGRPKGVEVTHRNVVDLALDGCFRNGAHRRVLVHSPHTFDASTYEMWVPLLGGGTAVVARVGRPDTAELARLVAEREVTALWLTAGLFAVMAEQHAECFGGVREVWAGGDVLSPSAVRTVLDACPGLTVVNGYGPTETTTFASRHRMTSAEQGAGPLPIGSPMDGSRLLVLDDRLRPVPPGVVGELYIGGDGVARGYAGRPGLTATRFVPDPASKAGGRVYRTGDLVRWDGAGRLHYVSRSDDQLKLRGFRVEPGELEAVLREQEGVANAVVAVRSDRLGERRMVAYVVPGDTASTGRDAAEQVDEWREVYDTMYGGTEVATDTVGEDFTGWNSSYTGLPIPLEEMRSWREAVLRRVRSLRPLRVLEIGVGSGLLLGPLAPETEEYWGTDFSAPVIERLRAQTRADRRLADKVTLRCGPAHDAEGLPAGYFDTVILNSVVQYFPDADYLGRVLDLAMDRLAPGGRVVLGDVRNHRTLRTFAAAVHRCRQPADGPAAVQAAVERAVLAEKELVVDPGFFTRYAETHPDTVAADIRLKQGTHHNELTRHRYEVVLHKAPAKPLDLGDLPEAVWASEVRELDDLDAALARHGGRLRLTRVPNARLAGEAAEWGAPAELGGTLDPAELEAWGAGRGLAVYCTWSPQAGDFFEAAVVPDVDAVCCDGLYRSTGAPAARLANVPAVSRRASRLPSVLRGRLVGRLPEFMMPAEIVVLDRLPLTENGKVDRAALPEPDPVDGEHRAPRTPREEQLAELFAEVLGLDRIGIDDDFFACGGHSLRLTRLAWQIREKLGVDVPIRTVFQYPTVAELAAQLTTDTDAQFEDPFAVLLPIRTEGQQPPLWWLHPGGGLSWPYLGFARHLDPGRPLYGIQARGFDGTTAPAASIEEMVEDYLEQVLRVQPSGPYHLLGWSFGGTLAHAMAAELQRRGHEVALLALLDAAPSSHFADLEALDESMVRRYLANYMGHLAGMEEYPSLVTTASSIFIGQMEQMRRFTSPRYRGDVVFFNALLDPETHDKRVMDEDLDVLWQDHVDGRVQRIDIPCAHNEMYWPRNAAEISRTINRMLRASQ

Formula C15210H23782N4338O4533S61

Absent Amino Acids

Common Amino Acids A

Mass 341900.16

PI 4.91

Basic Residues 382

Acidic Residues 432

Hydrophobic Residues 1351

Net Charge -119

Boman Index 668.63

Hydrophobicity -0.167

Aliphatic Index 90.17

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 460085

Absorbance 280nm 134.57

Polar Residues 556

number

376

A

279

R

50

N

225

D

23

C

207

E

76

Q

265

G

75

H

75

I

340

L

28

K

38

M

94

F

228

P

130

S

198

T

62

W

79

Y

287

V

Amino Acid Distribution

A: 376 R: 279 N: 50 D: 225 C: 23 E: 207 Q: 76 G: 265 H: 75 I: 75 L: 340 K: 28 M: 38 F: 94 P: 228 S: 130 T: 198 W: 62 Y: 79 V: 287

Length

3135

Formula

C15210H23782N4338O4533S61

Mass

341900.16

PI

4.91

Net Charge

-119

Boman Index

668.63

Hydrophobicity

-0.167

Evidence 1 Activity

Source & Reference

Database Source dbACP