TPDB

3D PDB MODEL

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TPDB ID TPDB42526

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

dbACP

Sequence_Type

standard

Has_Modification No

Description A 3115-aa standard natural anticancer peptide sequence curated from dbACP, with an available 3D structural model.

Sequence

MTDSPSAAHRDKVAIIGIGCRLPGHAGDHRSFWRNLIEGRDCLVPTPADRYDTTTLGSRDRAKPGRLTGGRGGYIDGFDEFDPHFFGISPREAEHMDPQQRKLLEVSWEALEDGGQRPAELAGRDVGVFIGAFTLDYKILQFADLGFETLAAHTATGTMMTMVSNRISHCLDFRGPSVSIDTACSSSLVAVHLACQSLQRGESELALAGGTLLHLAPQYTIAETKGGFLSPDGRSRAFDASADGYVRAEGVGVVVLKRLSDALRDGDPVHAVVIGSGVNQDGRTNGITVPSADAQATLIERVCAEAGVTPGSLQYVEAHGTSTPVGDPIEARALGRVLAQGRAPGARCYVGSVKTNIGHTEAAAGVAGLIKTALALRHRRIPPHLNLEQPNPAIDFAALPFEIPTAPVDWPEHQGPARAGVNSFGFGGTNAHVLLEEAPPRPPEEPRATARTPSLSVLPLSARHASGPAELAAGVRRELAAGVSLADLGHTLAHRRQHFEERLAVVHSPLGPPGSLDEVLAACERGEQHPRAVRGRLREPGAPRLVWVFTGMGPQWWGMGRELLDAEPVFREAVERCDREVRRQAGWSLLDELTRPEAESRMAETWLAQPANFAVQAGLAALWEHHGVRPDAVVGHSTGEIAAFHQAGVYGLEDAVRIALARSALQHRLAGTGVMLAANLSEEEAERLVRPYRDHVSVAAVNSPASVTLSGDRDTLRELAGRLEREQVFARFLDVEVPYHSVRMDPIEAELREALTGIAPRAAGLPLYPTAREGRARGPELDAVYWWENVRRPVRFRAAVDRLVDDGYTLFLEIGPHPVLGHSIRECLEGRAVEGVTLPSIRRREDEPERFARSLAELYTLGVDVDWSVLQPVGRPVPLPGYPWQRERYWVEPAPVEQIRLGRLDHPLLGRRASALQPTWESRLDTERLPYLADHRIEDSTVFPAAGYLEMAAQAVRALTGGDTATLADVEFSRALFLPDGEATTVQLAFAPEEAGFTIASLAGSGTGTPDRTVHASGVVRTGQPRRLAQPLDTGAVRARAGRRLDREACYGELAALGYHYGPAFRAIDEVWTGPGEALSLIRPTPGMGDGAADCHVHPVLLDACFQTMLTAMTPDDGRSAGIRLPAGIAELRLDAVGDRAALWAHATVTAESDEELVGDLALYAEDGTPLGRIGGFRAAAVDRGASSVKLGTIDGWLAEVVWEEAPTEAETPTEAPEDVGTAEGSGAGPGGSPAPGLVVFADEGGLGARMAEAVVARGGRCRLVRPGSRYRSGARHVTVRPDSAADLRRLFAELGPGFGAVVHLWNLDLPPLDTVGAADLDGIGTLGGYSLVLLAQVLPEAFPQGRLHIVTRGAQAVVPGEPVEPFGAPAWGIGRVLWQQELTGHSGKLIDLDPAGGPGEPEVLLRALTTDDGEGEIALRSGRRHLSRLRPPAGLTRPLPLRLRADGAYLVTGAFGALGRLLCRTLVRRGARRLVLLGRTGVPARGAWRGLDPGGPEGRRVAFLRELEALGAEVLVAAVDVTDAAAMEGWLAGRRAAGLPPVRGVFHLAGQVRDVLLPSLDREAFDAGYGPKAHGGYLLHRLLRDEPVEHFVLFASVASLLTTAGQVNYAAGNAFLDALAHHRRALGLPALSLDWGPWATGMIEELGLVAHYRDARGMSSLAPEAGMAVLERVIGQDRAQLLVAAVVDWPVFLSWYPTPPPLVSALAAAAAREVPAGQGGSLLAAFRAADEAARTALVAERFAALAAGVLRVRPEQVDADARLGSLGLDSLLAMELRARTHTELGVSLPVVALLSNGPVSELTERLHAGLTELAAAGGPVAETAVELFTDEACYPLTHNQQALWFLRQLNPDGFAYNIGGAVEVRAELDPELLFDAFRTLIARHPSLRVNITTEDGRPVQRVRPEAVADTGLLDVSGLPWDEVRARLVAEYRRPYDLERDPLVRLRLFRRAPDRWVLMKAVHHIVSDAISTFVFIEELFEVYHGLRTGRPAELAPVRARYLDFLNRRNRFLAGPEARRMLEYWREHLPREVPALELPTDRPRPPVQTDNGASEFFQLDDELSARVQTLAREHNVTVFTVLLTAYYLLLHRWSGQDEIVVGSPVTGRTEEELASVYGYFVNPLPLHVSLAGEPSVAELLGRVRDTVLGGLDHQEYPFVLLVEELGLQHDPSRSAVFQAMFILLTHKVGVERFGYTLEYIELPEEEGQFDVTLSAYEDRSDGRFHCVLKYNTDLFDAATVRRMAAHYQNLLDGLTRAEGERPAGRLPMLGAGERERIVTGFGGVGRRIDHDVPVHELIGKIAAQFPEAVAVSVPGGRRLGYRELDQRSRRVAASLRERGVGAGTVVAVRLAKSPELVIALLAVWRAGGAYLPLDPDHPAERLAELMENAGATLVLTDGRRGGAARLPGRPVTLDELDRPGTEERPEPAVDLDQTAYVIHTSGSTGRPKAVRVSHRNLASVFVAWQQEYRLDTDVRVHLQMAGLSFDVFTGDLVRALSSGGTLVLVDRDLLFDTARLYRTMRAEGVDCGEFVPSVARGLLAHCEREGLGLEFMRLVIVGSDAWRADEHHRLVALCGPGTRVVNSYGLTEATIDSAYYEGPAEGLEPGRMVPVGRPLPNSELYVLDRHGEPVPPGVAGELWIGGAGVADRCLGDPERTAERFVTLEPGGEPVRLYRTGDLGHWDAEGVLHLLGRRDGQVKVRGHRVETGEIEARLAARPELAQVCVTVRRDETGENVLCAYCVPAPGAAADARELRRHLAEQLPTYLIPAHFTELSALPLTANGKVDLDALPKPRAEAGPERYEPPVTLYETRMAAHWRSLLGLERPGLRDDFFEAGGSSIKLIQLIHHLRTEFNASVPVGRLFKTSTLHGMARTLEDVVTGRLPGAEPYLWFNPGADPAATVFCLPPAGGHGLVYRQLAARLPEHRFAAFNYLSGPDKAARYADLAEELHPGGPYTLFGYSLGGNLAFEIAGELERRGRAVDLVLIMDSYRMAEAVALGEEHLAEFEAELTEHLRRHTGSEIVARETVEQAREYLAHCAAHPSLGVLDAPIAVISDQDKLLRFAVDEPGGWHGGTAAGCTVREGHGRHAEMLDGSFLDGNAELVRALLTGGAANGRA

FASTA

>TPDB42526|Anticancer|length=3115
MTDSPSAAHRDKVAIIGIGCRLPGHAGDHRSFWRNLIEGRDCLVPTPADRYDTTTLGSRDRAKPGRLTGGRGGYIDGFDEFDPHFFGISPREAEHMDPQQRKLLEVSWEALEDGGQRPAELAGRDVGVFIGAFTLDYKILQFADLGFETLAAHTATGTMMTMVSNRISHCLDFRGPSVSIDTACSSSLVAVHLACQSLQRGESELALAGGTLLHLAPQYTIAETKGGFLSPDGRSRAFDASADGYVRAEGVGVVVLKRLSDALRDGDPVHAVVIGSGVNQDGRTNGITVPSADAQATLIERVCAEAGVTPGSLQYVEAHGTSTPVGDPIEARALGRVLAQGRAPGARCYVGSVKTNIGHTEAAAGVAGLIKTALALRHRRIPPHLNLEQPNPAIDFAALPFEIPTAPVDWPEHQGPARAGVNSFGFGGTNAHVLLEEAPPRPPEEPRATARTPSLSVLPLSARHASGPAELAAGVRRELAAGVSLADLGHTLAHRRQHFEERLAVVHSPLGPPGSLDEVLAACERGEQHPRAVRGRLREPGAPRLVWVFTGMGPQWWGMGRELLDAEPVFREAVERCDREVRRQAGWSLLDELTRPEAESRMAETWLAQPANFAVQAGLAALWEHHGVRPDAVVGHSTGEIAAFHQAGVYGLEDAVRIALARSALQHRLAGTGVMLAANLSEEEAERLVRPYRDHVSVAAVNSPASVTLSGDRDTLRELAGRLEREQVFARFLDVEVPYHSVRMDPIEAELREALTGIAPRAAGLPLYPTAREGRARGPELDAVYWWENVRRPVRFRAAVDRLVDDGYTLFLEIGPHPVLGHSIRECLEGRAVEGVTLPSIRRREDEPERFARSLAELYTLGVDVDWSVLQPVGRPVPLPGYPWQRERYWVEPAPVEQIRLGRLDHPLLGRRASALQPTWESRLDTERLPYLADHRIEDSTVFPAAGYLEMAAQAVRALTGGDTATLADVEFSRALFLPDGEATTVQLAFAPEEAGFTIASLAGSGTGTPDRTVHASGVVRTGQPRRLAQPLDTGAVRARAGRRLDREACYGELAALGYHYGPAFRAIDEVWTGPGEALSLIRPTPGMGDGAADCHVHPVLLDACFQTMLTAMTPDDGRSAGIRLPAGIAELRLDAVGDRAALWAHATVTAESDEELVGDLALYAEDGTPLGRIGGFRAAAVDRGASSVKLGTIDGWLAEVVWEEAPTEAETPTEAPEDVGTAEGSGAGPGGSPAPGLVVFADEGGLGARMAEAVVARGGRCRLVRPGSRYRSGARHVTVRPDSAADLRRLFAELGPGFGAVVHLWNLDLPPLDTVGAADLDGIGTLGGYSLVLLAQVLPEAFPQGRLHIVTRGAQAVVPGEPVEPFGAPAWGIGRVLWQQELTGHSGKLIDLDPAGGPGEPEVLLRALTTDDGEGEIALRSGRRHLSRLRPPAGLTRPLPLRLRADGAYLVTGAFGALGRLLCRTLVRRGARRLVLLGRTGVPARGAWRGLDPGGPEGRRVAFLRELEALGAEVLVAAVDVTDAAAMEGWLAGRRAAGLPPVRGVFHLAGQVRDVLLPSLDREAFDAGYGPKAHGGYLLHRLLRDEPVEHFVLFASVASLLTTAGQVNYAAGNAFLDALAHHRRALGLPALSLDWGPWATGMIEELGLVAHYRDARGMSSLAPEAGMAVLERVIGQDRAQLLVAAVVDWPVFLSWYPTPPPLVSALAAAAAREVPAGQGGSLLAAFRAADEAARTALVAERFAALAAGVLRVRPEQVDADARLGSLGLDSLLAMELRARTHTELGVSLPVVALLSNGPVSELTERLHAGLTELAAAGGPVAETAVELFTDEACYPLTHNQQALWFLRQLNPDGFAYNIGGAVEVRAELDPELLFDAFRTLIARHPSLRVNITTEDGRPVQRVRPEAVADTGLLDVSGLPWDEVRARLVAEYRRPYDLERDPLVRLRLFRRAPDRWVLMKAVHHIVSDAISTFVFIEELFEVYHGLRTGRPAELAPVRARYLDFLNRRNRFLAGPEARRMLEYWREHLPREVPALELPTDRPRPPVQTDNGASEFFQLDDELSARVQTLAREHNVTVFTVLLTAYYLLLHRWSGQDEIVVGSPVTGRTEEELASVYGYFVNPLPLHVSLAGEPSVAELLGRVRDTVLGGLDHQEYPFVLLVEELGLQHDPSRSAVFQAMFILLTHKVGVERFGYTLEYIELPEEEGQFDVTLSAYEDRSDGRFHCVLKYNTDLFDAATVRRMAAHYQNLLDGLTRAEGERPAGRLPMLGAGERERIVTGFGGVGRRIDHDVPVHELIGKIAAQFPEAVAVSVPGGRRLGYRELDQRSRRVAASLRERGVGAGTVVAVRLAKSPELVIALLAVWRAGGAYLPLDPDHPAERLAELMENAGATLVLTDGRRGGAARLPGRPVTLDELDRPGTEERPEPAVDLDQTAYVIHTSGSTGRPKAVRVSHRNLASVFVAWQQEYRLDTDVRVHLQMAGLSFDVFTGDLVRALSSGGTLVLVDRDLLFDTARLYRTMRAEGVDCGEFVPSVARGLLAHCEREGLGLEFMRLVIVGSDAWRADEHHRLVALCGPGTRVVNSYGLTEATIDSAYYEGPAEGLEPGRMVPVGRPLPNSELYVLDRHGEPVPPGVAGELWIGGAGVADRCLGDPERTAERFVTLEPGGEPVRLYRTGDLGHWDAEGVLHLLGRRDGQVKVRGHRVETGEIEARLAARPELAQVCVTVRRDETGENVLCAYCVPAPGAAADARELRRHLAEQLPTYLIPAHFTELSALPLTANGKVDLDALPKPRAEAGPERYEPPVTLYETRMAAHWRSLLGLERPGLRDDFFEAGGSSIKLIQLIHHLRTEFNASVPVGRLFKTSTLHGMARTLEDVVTGRLPGAEPYLWFNPGADPAATVFCLPPAGGHGLVYRQLAARLPEHRFAAFNYLSGPDKAARYADLAEELHPGGPYTLFGYSLGGNLAFEIAGELERRGRAVDLVLIMDSYRMAEAVALGEEHLAEFEAELTEHLRRHTGSEIVARETVEQAREYLAHCAAHPSLGVLDAPIAVISDQDKLLRFAVDEPGGWHGGTAAGCTVREGHGRHAEMLDGSFLDGNAELVRALLTGGAANGRA

Formula C14917H23562N4386O4395S62

Absent Amino Acids

Common Amino Acids A

Mass 336655.65

PI 5.56

Basic Residues 422

Acidic Residues 411

Hydrophobic Residues 1338

Net Charge -77

Boman Index 703.24

Hydrophobicity -0.141

Aliphatic Index 92.51

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 329935

Absorbance 280nm 98.00

Polar Residues 484

number

396

A

302

R

40

N

171

D

27

C

240

E

68

Q

321

G

96

H

71

I

376

L

24

K

35

M

94

F

208

P

125

S

155

T

41

W

69

Y

256

V

Amino Acid Distribution

A: 396 R: 302 N: 40 D: 171 C: 27 E: 240 Q: 68 G: 321 H: 96 I: 71 L: 376 K: 24 M: 35 F: 94 P: 208 S: 125 T: 155 W: 41 Y: 69 V: 256

Length

3115

Formula

C14917H23562N4386O4395S62

Mass

336655.65

PI

5.56

Net Charge

-77

Boman Index

703.24

Hydrophobicity

-0.141

Evidence 1 Activity

Source & Reference

Database Source dbACP