TPDB

3D PDB MODEL

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TPDB ID TPDB42468

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

dbACP

Sequence_Type

standard

Has_Modification No

Description A 735-aa standard natural anticancer peptide sequence curated from dbACP, with an available 3D structural model.

Sequence

MSAETYRDAWGIPHLRADSPEELARAQGRVTARDRAWQLEAERHRAQGTSAAFLGPEALSWDRLARRARLADTARRCFIALEEKDPETAAWVRAYVHGVNEGLALHRGGDGPGDREGPGDREGSHPLDGSPRRDDPRRPPAPEFARAALAPGRWEPWTPLAVWLATHILFAGFPAKLWREHITARLGPDAVALFAADGPGTTGSNGWLLSGERTTTGHALIAGDPHRWIEDPGVYQQVHLSCPEFDVVGLAVPGVPGVAHFGHTGTVAWAITNAMSDYQDLYHERLRRTGAGVEALGPDGTWRRAARHTETIRVAGEGTVEVEVIETDRGPVVAGGPEGLDDGTPAALSLRYPPRVTSDLGFGALLPLLRARTVADVDRALDAWAEPVNVVQAADTGGGLLHRVAGRVPVRAEANGLRPVPAWEPGHEWTGWHTPPRAGLADGAAVMANQRGLATPLGVEFAAPHRADRIAALLAGRRRWSAADLSAIHTDTHLGSAGPLLAHLTALTGLGPEATDLRDRVLAWDRRMDARSTGAAAYAAVRAAVVRRLAAHPVLAPASVAPAYPEVLQPWLALVPRVAYALEHLLRADDLYGIDRAAVVRAALEEVAARPPAGPWGDTHRLTPWRALPDPAAPADAPALSGDHDCVLCTSSVPGLTDRAARGPAARYVWDLADRGNSRWVVPHGASGTPGSSHHRDQQPLWLAGELVPVITDFDRLTLICTHTHTHTSTEETDA

FASTA

>TPDB42468|Anticancer|length=735
MSAETYRDAWGIPHLRADSPEELARAQGRVTARDRAWQLEAERHRAQGTSAAFLGPEALSWDRLARRARLADTARRCFIALEEKDPETAAWVRAYVHGVNEGLALHRGGDGPGDREGPGDREGSHPLDGSPRRDDPRRPPAPEFARAALAPGRWEPWTPLAVWLATHILFAGFPAKLWREHITARLGPDAVALFAADGPGTTGSNGWLLSGERTTTGHALIAGDPHRWIEDPGVYQQVHLSCPEFDVVGLAVPGVPGVAHFGHTGTVAWAITNAMSDYQDLYHERLRRTGAGVEALGPDGTWRRAARHTETIRVAGEGTVEVEVIETDRGPVVAGGPEGLDDGTPAALSLRYPPRVTSDLGFGALLPLLRARTVADVDRALDAWAEPVNVVQAADTGGGLLHRVAGRVPVRAEANGLRPVPAWEPGHEWTGWHTPPRAGLADGAAVMANQRGLATPLGVEFAAPHRADRIAALLAGRRRWSAADLSAIHTDTHLGSAGPLLAHLTALTGLGPEATDLRDRVLAWDRRMDARSTGAAAYAAVRAAVVRRLAAHPVLAPASVAPAYPEVLQPWLALVPRVAYALEHLLRADDLYGIDRAAVVRAALEEVAARPPAGPWGDTHRLTPWRALPDPAAPADAPALSGDHDCVLCTSSVPGLTDRAARGPAARYVWDLADRGNSRWVVPHGASGTPGSSHHRDQQPLWLAGELVPVITDFDRLTLICTHTHTHTSTEETDA

Formula C3480H5419N1063O1018S9

Absent Amino Acids

Common Amino Acids A

Mass 78725.36

PI 6.13

Basic Residues 107

Acidic Residues 90

Hydrophobic Residues 310

Net Charge -11

Boman Index 149.20

Hydrophobicity -0.280

Aliphatic Index 83.14

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 148640

Absorbance 280nm 188.81

Polar Residues 107

number

121

A

74

R

7

N

51

D

5

C

39

E

11

Q

71

G

31

H

14

I

73

L

2

K

4

M

11

F

61

P

25

S

48

T

24

W

11

Y

52

V

Amino Acid Distribution

A: 121 R: 74 N: 7 D: 51 C: 5 E: 39 Q: 11 G: 71 H: 31 I: 14 L: 73 K: 2 M: 4 F: 11 P: 61 S: 25 T: 48 W: 24 Y: 11 V: 52

Length

735

Formula

C3480H5419N1063O1018S9

Mass

78725.36

PI

6.13

Net Charge

-11

Boman Index

149.20

Hydrophobicity

-0.280

Evidence 1 Activity

Source & Reference

Database Source dbACP