TPDB

3D PDB MODEL

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TPDB ID TPDB41917

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

dbACP

Sequence_Type

standard

Has_Modification No

Description A 1079-aa standard natural anticancer peptide sequence curated from dbACP, with an available 3D structural model.

Sequence

MQETAPDPVAGRQPAPAAGPEDAVAALAHACAAALASDPASVRLAARLKVASVLLGRASPAPDASWRDLVRHVGTDDGRSEAEEAWANASAAAGATAERLGRYELRALRLMRDDPDLPHTRHGLLTPEETEAVVARGAGPLRPLPGRRFHELFEERVRRHPDAVAVVHGTTTRTYRELNDDANRIAGALLREGLAPEDVVAVVTGRHPLWPAAVLAVFKAGGCYLPLEPEFPASRIARTLTRSECRWVLSDPDVASLDEALNGRDTIRRMTVGDLARGDGPTRDPGVAVAGDQLAYVYFTSGSTGEPKGAMCEHDGFLNHLYAKIEDLGVQEGDTVGQTAPQCFDISLWQLVSPFLVGGRVLLVEQEAVLDVARFVDLVNRHRVQVLQLVPTYLELVLAEAARGRAALPHLRVMAVTGEALKKELVRRWFEQFPGVPLVNCYGLTEVSDDSHHGVMHTVPDHRSVPLGDTIRNCRVYVMDEQLHLVPDGAPGEIVIAGVCVGRGYVNDPDRTAAVYHQDPLRPAERLYRSGDFGRRLPSGELEYLGRRDAQVKISGFRIEIGEIEDRLLQVPGVRDGAVVVAGTDDAPQLVAYYTGEDAPDGAGTAHALGTALPHYMVPHRLHRVRELPLSGNGKIDKKALTARARDNAHARGSAGTGAPRLDTPAERRVAAVWARLLRVPEDRIGRDSRFTDLGGTSLTAIRLAIELDRRVTVAELRDTPTVADVAALLDGKSAPARATAPAGPAPATTPARPAEGPAPLPLLDCRAADPEPDPAARATAHRAPALAALAASGAVMLRGVGARTPADVARVAAALGIEPLTEREGFAPRTALAPGVYSGSHWPAEDPMCMHHELSHAATVPGTLLFACLTAPDSGGRTTVADSQQVLAALPSGLTARFAEHGWLLRRAYHDVGLSWPEAFGSTDRASVDAYCAEAAVEPTWLADGSLLTRQRRAAVVPHPRTGAPCWFNQIAFLNGLTLEPAIREYLTDVYGPGGLPFDTAAGDGGPVTAGTVEEINAVYDRFTVGEPWQQGDVLLVDNIRTAHAREPYEGAREIAVVLGDPVRLPGHVLPLSDGGPS

FASTA

>TPDB41917|Anticancer|length=1079
MQETAPDPVAGRQPAPAAGPEDAVAALAHACAAALASDPASVRLAARLKVASVLLGRASPAPDASWRDLVRHVGTDDGRSEAEEAWANASAAAGATAERLGRYELRALRLMRDDPDLPHTRHGLLTPEETEAVVARGAGPLRPLPGRRFHELFEERVRRHPDAVAVVHGTTTRTYRELNDDANRIAGALLREGLAPEDVVAVVTGRHPLWPAAVLAVFKAGGCYLPLEPEFPASRIARTLTRSECRWVLSDPDVASLDEALNGRDTIRRMTVGDLARGDGPTRDPGVAVAGDQLAYVYFTSGSTGEPKGAMCEHDGFLNHLYAKIEDLGVQEGDTVGQTAPQCFDISLWQLVSPFLVGGRVLLVEQEAVLDVARFVDLVNRHRVQVLQLVPTYLELVLAEAARGRAALPHLRVMAVTGEALKKELVRRWFEQFPGVPLVNCYGLTEVSDDSHHGVMHTVPDHRSVPLGDTIRNCRVYVMDEQLHLVPDGAPGEIVIAGVCVGRGYVNDPDRTAAVYHQDPLRPAERLYRSGDFGRRLPSGELEYLGRRDAQVKISGFRIEIGEIEDRLLQVPGVRDGAVVVAGTDDAPQLVAYYTGEDAPDGAGTAHALGTALPHYMVPHRLHRVRELPLSGNGKIDKKALTARARDNAHARGSAGTGAPRLDTPAERRVAAVWARLLRVPEDRIGRDSRFTDLGGTSLTAIRLAIELDRRVTVAELRDTPTVADVAALLDGKSAPARATAPAGPAPATTPARPAEGPAPLPLLDCRAADPEPDPAARATAHRAPALAALAASGAVMLRGVGARTPADVARVAAALGIEPLTEREGFAPRTALAPGVYSGSHWPAEDPMCMHHELSHAATVPGTLLFACLTAPDSGGRTTVADSQQVLAALPSGLTARFAEHGWLLRRAYHDVGLSWPEAFGSTDRASVDAYCAEAAVEPTWLADGSLLTRQRRAAVVPHPRTGAPCWFNQIAFLNGLTLEPAIREYLTDVYGPGGLPFDTAAGDGGPVTAGTVEEINAVYDRFTVGEPWQQGDVLLVDNIRTAHAREPYEGAREIAVVLGDPVRLPGHVLPLSDGGPS

Formula C5062H8037N1509O1520S24

Absent Amino Acids

Common Amino Acids A

Mass 115125.14

PI 5.63

Basic Residues 145

Acidic Residues 139

Hydrophobic Residues 459

Net Charge -24

Boman Index 253.13

Hydrophobicity -0.169

Aliphatic Index 89.06

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 106520

Absorbance 280nm 92.53

Polar Residues 175

number

160

A

101

R

15

N

74

D

13

C

65

E

22

Q

98

G

33

H

22

I

112

L

11

K

11

M

22

F

86

P

39

S

63

T

13

W

23

Y

96

V

Amino Acid Distribution

A: 160 R: 101 N: 15 D: 74 C: 13 E: 65 Q: 22 G: 98 H: 33 I: 22 L: 112 K: 11 M: 11 F: 22 P: 86 S: 39 T: 63 W: 13 Y: 23 V: 96

Length

1079

Formula

C5062H8037N1509O1520S24

Mass

115125.14

PI

5.63

Net Charge

-24

Boman Index

253.13

Hydrophobicity

-0.169

Evidence 1 Activity

Source & Reference

Database Source dbACP