TPDB

3D PDB MODEL

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TPDB ID TPDB41736

Activity

Anticancer

Activity_category_statistics

Cancer-related peptides

Database_Source

dbACP

Sequence_Type

standard

Has_Modification No

Description A 321-aa standard natural anticancer peptide sequence curated from dbACP, with an available 3D structural model.

Sequence

MGLYPEIEPYDHGMLDVGDGNHVYWETCGNPHGKPAVVLHGGPGSRATPGHRRYFDPAAYRIVLLDQRGAGRSRPRASAHDTDMGVNTTAHLMADLERLRAHLGIERWLVWGVSFGSFLGLRYAQTHPGVVTELVLTGVATGSNREVDLLTRGLGKLFPEAYEQLLAGLPPDEREGNHAAAYHRLLESPDAAVRERAARAWTDWETATIPAPPRSVARYEDPAFRLGFARTVTHYWGNDHFLGDGNDEGVVLRDAPLLKGVPGTLVQGSLDFGNLLGTVWRLHHAWPDSELVLVDEAGHDAGAVGDEVLVAATDRYARGAA

FASTA

>TPDB41736|Anticancer|length=321
MGLYPEIEPYDHGMLDVGDGNHVYWETCGNPHGKPAVVLHGGPGSRATPGHRRYFDPAAYRIVLLDQRGAGRSRPRASAHDTDMGVNTTAHLMADLERLRAHLGIERWLVWGVSFGSFLGLRYAQTHPGVVTELVLTGVATGSNREVDLLTRGLGKLFPEAYEQLLAGLPPDEREGNHAAAYHRLLESPDAAVRERAARAWTDWETATIPAPPRSVARYEDPAFRLGFARTVTHYWGNDHFLGDGNDEGVVLRDAPLLKGVPGTLVQGSLDFGNLLGTVWRLHHAWPDSELVLVDEAGHDAGAVGDEVLVAATDRYARGAA

Formula C1556H2383N457O457S5

Absent Amino Acids

Common Amino Acids G

Mass 34964.13

PI 5.66

Basic Residues 46

Acidic Residues 42

Hydrophobic Residues 134

Net Charge -11

Boman Index 64.54

Hydrophobicity -0.310

Aliphatic Index 83.61

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 60390

Absorbance 280nm 172.72

Polar Residues 52

number

37

A

27

R

8

N

23

D

1

C

19

E

4

Q

38

G

16

H

4

I

36

L

3

K

4

M

8

F

20

P

10

S

18

T

8

W

11

Y

26

V

Amino Acid Distribution

A: 37 R: 27 N: 8 D: 23 C: 1 E: 19 Q: 4 G: 38 H: 16 I: 4 L: 36 K: 3 M: 4 F: 8 P: 20 S: 10 T: 18 W: 8 Y: 11 V: 26

Length

321

Formula

C1556H2383N457O457S5

Mass

34964.13

PI

5.66

Net Charge

-11

Boman Index

64.54

Hydrophobicity

-0.310

Evidence 1 Activity

Source & Reference

Database Source dbACP